Precore/core region mutations of hepatitis B virus related to clinical severity

Table 1 Mutations in the hepatitis B virus preC/C region reported by previous literatures

Regions	Type of mutation	Mutations				HBV genotype	MHC class	Ref.
		Amino acid	Changes	Nucelotide	Changes
preCore	AS	1	M1L/T/I	1814-1816	A1814T/C, T1815C, G1816T/A	A		[69-72]
	AS	2	Q2Stop	1817	C1817T	A		[71, 73]
	Ins		Insertion TT	1821	1821-1825			[74]
	Ins		Insertion TT	1825	1825-1826			[71]
	Del		T deletion	1839	1839del			[72]
	Ins		Insertion T	1839	1839-1840			[71]
	AS	15	P15S	1856	C1856T			[75]
			NC	1858	T1858C	A/B/E		[76]
	AS	17	V17F	1862	G1862T	A1		[95]
	AS	26	W26R	1889	T1889A	B/C		[77]
	Ins	36	Insertion 36nt	1895	1895-1896			[78]
	AS	28	W28Stop	1896	G1896A	B/C/C2/D		[29, 61, 77, 79, 80]
	AS	29	G29D	1899	G1899A	C2		[29]
Core	AS	5	P5T/L/H	1913-1915	C1913A, C1914A/T, G1915A/C	B/C2	II	[29, 61, 81]
			P5R	1914	C1914G	A/D		[79]
			NC	1915	G1915A/C, A1915T	B/C		[77, 82]
	AS	12	T12S	1934	A1934T	A/C/D	II	[83]
	AS	21	S21H	1961-1962	T1961C, C1962A	A/C/D	I	[68, 83]
	AS	27	V/I27I/V	1979	G1979A, A1979G	A/B/C/D	I	[68, 77, 83]
			NC	1981	C1981A	A/D		[68]
	AS	32	D32N/H	1994	G1994A/C	C2	Immuno-inactive	[29]
	AS	34	NC	2002	C2002A	A/D	Immuno-inactive	[68]
	AS	35	S35L	2004	C2004T	A/D	Immuno-inactive	[68]
	AS	43	E43K	2027	G2027A	C2	Immuno-inactive	[29]
			NC	2029	G2029A	A/D		[68]
	AS	45	NC	2035	T2035A/G	A/D	Immuno-inactive	[68]
	AS	48	NC	2044	T2044C	B/C	Immuno-inactive	[77]
	AS	49	NC	2047	A2047C	A/D	Immuno-inactive	[68]
	AS	50	P50Y/H/A	2048-2049	C2048T/G, C2049A	B/C/C2	II	[29, 84]
	AS	55	L55I	2063	C2063A	A/D	II	[68]
	AS	59	I59F	2075	A2075T	A/C/D	II	[83]
			NC	2077	T2077A/C	B/C		[77]
	AS	60	L60V	2078	C2078G		II	[85]
			NC	2080	C2080A	A/D		[68]
Core	AS	64	E/K64D	2090-2092	A2090G, A2092T/C	A/C/D	II	[68, 83]
	AS	65	L65V	2093	C2093G	A/D	II	[68]
	AS	67	T67N	2100	C2100A	A/C/D	II	[68, 83]
	AS	77	E77Q	2129	G2129C	B/C	Immuno-inactive	[84]
			NC	2131	A2131G	A/D		[68]
	AS	78	NC	2134	C2134T	B/C	Immuno-inactive	[77]
	Del		105nt deletion	2134-2238	2134-2238			[86]
	AS	79	NC	2137	A2137G/T/C	B/C	Immuno-inactive	[77]
	AS	83	E83D	2149	A2149T/C	C2	II	[29]
	Del		105nt deletion	2150-2254	2150-2254			[86]
	AS	87	S87R	2161	C2161G	B/C	II	[77]
	AS	89	NC	2167	T2167C	A/D	I and II	[68]
	AS	92	NC	2176	T2176C	B/C	I and II	[77]
	AS	95	L95I	2183	C2183A	A/D	I and II	[68]
	AS	97	I97F/L	2189-2191	A2189T/C, C2191T	A/B/C/C2/D	II	[29, 77, 83, 85]
			NC	2191	C2191A/T	A/D		[68]
	AS	100	L100I	2198	C2198A	A/C/C2/D	II	[29, 83]
	AS	101	NC	2201	T2201C	B/C	II	[77]
	Del		130nt deletion	2204-2333	2204-2333			[86]
	AS	107	NC	2221	C2221T	B/C	Immuno-inactive	[77]
	AS	113	E113Q	2237	G2237C	A/D	Immuno-inactive	[68]
	AS	115	NC	2245	C2245T	B/C	Immuno-inactive	[77]
	AS	117	NC	2251	G2251A	B/C	II	[77]
	AS	119	NC	2257	G2257A	A/D	II	[68]
	AS	120	NC	2260	G2260A	B/C	II	[77]
	AS	126	NC	2278	T2278A	A/D	II	[68]
	AS	130	P130S/T	2288	C2288T/A	B/C	II	[74, 77]
			NC	2290	C2290T	B/C		[77]
	AS	131	A131P/N/G	2291-2293	G2291C/A, C2292A/G, T2293C	A/C/C2/D	I and II	[29, 83]
			NC	2293	C2293T	A/D		[68]
	AS	134	NC	2302	A2302G	A/D	I	[68]
	AS	135	P135Q/S/A	2303-2304	C2303T/G, C2304A	A/B/C/D	I	[61, 68, 83]
	AS	142	NC	2326	A2326T	A/D	I and II	[68]
	AS	145	NC	2335	A2335G	A/D	I and II	[68]
	AS	149	V149I	2345	G2345A	B/C	I and II	[84]
	AS	181	S181P/H	2441-2442	T2441C, C2442A	C2	Immuno-inactive	[29]
	AS	182	Q182K/Stop	2444-2445	C2444A/T, A2445G	C2	Immuno-inactive	[29]

AS: Amino acid substitution; Del: Deletion; Ins: Insertion; MHC: Major histocompatibility complex; NC: No change.