Combined mesenchymal stem cell transplantation and interleukin-1 receptor antagonism after partial hepatectomy

Figure 6 Histologic analysis of liver tissues. Hematoxylin and eosin staining of liver sections taken seven days post-hepatectomy in A: Normal, sham-operated control; B: After hepatectomy (black stars indicate complete necrosis in liver organization; black arrow represents interlobular fiber structure); C: With MSC transplantation (blue star shows a hepatic lobule near the central part and necrosis of hepatocytes; black arrow shows the fibrous tissue and some inflammatory cell infiltration); D: Treatment with IL-1Ra (black stars show hemorrhage and necrosis in the hepatic lobe; blue star represents the liver cells in the hemorrhagic area); E: Combined MSC transplantation and IL-1Ra treatment (black star shows a normal hepatic lobule; black arrows indicate fatty degeneration of hepatocytes and hepatic sinus dilation with hyperemia in central hepatic lobe) (magnification × 100, scale bar = 100 μm); F: Histopathologic scores of liver tissues after hepatectomy. ^aP < 0.05 vs hepatectomy + MSCs + IL-1Ra; ^bP < 0.01 vs hepatectomy. IL-1Ra: Interleukin-1 receptor antagonist; MSC: Mesenchymal stem cell transplantation.