Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease

Figure 1 Chronic alcohol enhances DEN induced hepatic injury. A: Experimental design of the adult mouse model of early hepatocellular carcinoma. B: Body weight of mice in each group per week. C: Three - five mice from each experimental group were bled every week and serum ALT was measured. The graph represents mean ALT levels of each group. In graphs B and C, values are given as mean ± SD, Dunnett’s multiple comparison were used to compare the means of multiple groups; (^aP < 0.05 vs pair fed saline injected mice, ^cP < 0.05 vs pair fed DEN injected mice). ALT: Alanine aminotransferase; DEN: Diethyl nitrosamine; AFP: α-fetoprotein; MRI: Magnetic resonance imaging.