Predictive effects of bilirubin on response of colorectal cancer to irinotecan-based chemotherapy

Table 4 Association between serum total/unconjugated bilirubin levels and response to treatment

	Objective response1		Simple analysis		Multiple analysis2
	n	Yes (%)	OR (95%CI)	P value	OR (95%CI)	P value
Serum total bilirubin
> 13.0	24	4 (16.7)	1.000 (ref.)		1.000 (ref.)
≤ 13.0	96	38 (39.6)	3.276 (1.038-10.333)	0.043	3.874 (1.127-13.319)	0.032
Serum unconjugated bilirubin
> 4.1	107	33 (30.8)	1.000 (ref.)		1.000 (ref.)
≤ 4.1	13	9 (69.2)	5.045 (1.450-17.561)	0.011	5.923 (1.561-22.479)	0.009

¹Yes, partial and complete response;

²Multiple analyses were adjusted for age, sex, KPS, histology, primary tumor site and treatment regimen. KPS: Karnofsky performance status.