Transient elastography compared to liver biopsy and morphometry for predicting fibrosis in pediatric chronic liver disease: Does etiology matter?

Table 2 Clinical performance of liver stiffness in predicting individual Ishak fibrosis stages in all the patients

Ishak fibrosis stage	Cut-off (kPa)	AUROC	P value	Sensitivity	Specificity	PPV	NPV
≥ F1	4.75	0.807	0.039	81.4	75.0	98.6	15.7
≥ F2	6.65	0.947	< 0.0001	88.7	86.5	90.4	84.2
≥ F3	8.25	0.960	< 0.0001	89.5	90.4	87.2	92.2
≥ F4	13.0	0.993	< 0.0001	100	96.9	92.9	100
≥ F5	18.0	0.985	< 0.0001	100	97.2	90.0	100
F6	29.5	0.941	< 0.0001	85.7	91.6	46.2	98.7

AUROC: Area under receiver operating characteristic curve; PPV: Positive predictive value; NPV: Negative predictive value.