Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor

Table 3 Characteristics of patients with infection according to appropriate or inappropriate antimicrobial-therapy n (%)

Characteristic	All patients with infection (n = 1042)	Appropriate therapy (n = 948)	Inappropriate therapy (n = 94)	OR (95%CI)	P value
Age (yr), mean ± SD (range)	61 ± 16 (16-95)	61 ± 16 (16-95)	61 ± 14 (21-88)	1.003 (0.99-1.017)	> 0.20
Male sex	622 (60.0)	376 (39.7)		0.747 (0.488-1.143)	0.18
Days on ICU, mean ± SD (range)	8.12 ± 12 (1-217)	7.68 ± 11.958 (1-217)	10.02 ± 11.134 (1-59)	1.011 (0.998-0.024)	0.092
ICU-mortality	324 (31.3)	287 (30.3)	37 (39.4)	0.669 (0.432-1.035)	0.071
Hospital-mortality	350 (33.6)	310 (32.7)	40 (42.6)	0.656 (0.426-1.009)	0.055
Severity score on admission day
SAPS II, mean ± SD (range)	38.67 ± 15.64 (5-93)	38.54 ± 15.82 (5-93)	39.95 ± 13.78 (8-68)	1.006 (0.992-1.020)	> 0.20
TISS, mean ± SD (range)	11.57 ± 9.11 (0-55)	11.74 ± 9.25 (0-55)	9.86 ± 7.42 (0-28)	0.976 (0.951-1.002)	0.071
Highest severity score within 7 d after admission
SAPS II, mean ± SD (range)	43.88 ± 16.57 (6-93)	43.68 ± 16.71 (6-93)	45.87 ± 15.09 (8-81)	1.008 (0.994-1.022)	> 0.20
TISS. mean ± SD (range)	14.65 ± 9.14 (0-55)	14.68 ± 9.27 (0-55)	14.32 ± 7.73 (0-38)	0.996 (0.971-1.021)	> 0.20
Type of Admission					0.0022
Internal Medicine ICU	550 (52.8)	486 (51.3)	64 (68.1)
Cardiology ICU	491 (47.1)	461 (48.7)	30 (31.9)
Source of admission					> 0.20
Emergency department	455 (43.7)	418 (44.1)	37 (39.4)	Reference
Other hospital	187 (17.9)	170 (17.9)	17 (18.1)	0.425 (0.153-1.179)	0.10
Hospital ward	337 (32.3)	305 (32.2)	32 (34.0)	0.48 (0.162-1.429)	0.19
Operating room	34 (3.3)	31 (3.3)	3 (3.2)	0.504 (0.18-1.411)	0.19
Surgical IMC/ICU	29 (2.7)	24 (2.6)	5 (5.3)	0.465 (0.101-2.14)	> 0.20
Comorbid conditions	806 (77.4)	729 (76.9)	77 (81.9)	0.842 (0.498-1.424)	> 0.20
COPD	149 (14.3)	137 (14.5)	12 (12.8)	1.154 (0.613-2.172)	> 0.20
Heart failure (EF < 30%)	55 (5.3)	50 (5.3)	5 (5.3)	0.991 (0.385-2.549)	> 0.20
Coronary artery disease	211 (20.2)	195 (20.6)	16 (17.0)	1.262 (0.721-2.211)	> 0.20
Chronic renal failure	202 (19.4)	182 (19.2)	20 (21.3)	0.879 (0.523-1.478)	> 0.20
Diabetes mellitus	247 (23.7)	220 (23.2)	27 (28.7)	0.750 (0.468-1.202)	> 0.20
Liver-cirrhosis	118 (11.3)	100 (10.5)	18 (19.1)	0.498 (0.286-0.866)	0.014
Cancer	140 (13.4)	122 (12.9)	18 (19.1)	0.624 (0.361-1.079)	0.091
Hematologic neoplasia	72 (6.9)	68 (7.2)	4 (4.3)	1.739 (0.620-4.877)	> 0.20
HIV	61 (5.9)	51 (5.4)	10 (10.6)	0.478 (0.234-0.975)	0.042
Immunosuppressive Tx.	77 (7.4)	69 (7.3)	8 (8.5)	0.844 (0.393-1.813)	> 0.20
Chemotherapy	53 (5.1)	47 (5.0)	6 (6.4)	2.634 (1.691-4.102)	0.000018
Number of cormobid conditions					> 0.20
0	236	219 (23.1)	17 (18.1)
1	336	304 (32.1)	32 (34.0)
2	241	219 (23.1)	22 (23.4)
3	151	138 (14.6)	13 (13.8)
> 3	78	68 (7.2)	10 (10.6)
Mechanical ventilation	677 (65.0)	621 (65.5)	56 (59.6)	1.289 (0.836-1.987)	> 0.20
Hemodialysis	213 (20.4)	194 (20.5)	19 (20.2)	1.016 (0.599-1.721)	> 0.20

Appropriate therapy: Patients who received appropriate antimicrobial-therapy; Inappropriate therapy: Patients who received inappropriate antimicrobial-therapy; SAPS II: Simplified Acute Physiology Score II; TISS: Therapeutic Intervention Scoring System; ICU: Intensive care unit; IMC: Internal Medicine ICU includes patients from Gastroenterology, Hepatology, Pulmonology, Endocrinology, Oncology, Hematology, Infectiology, Rheumatology departments, while Cardiology-ICU include patients from Cardiology, Angiology, Nephrology department; EF: Ejection fraction.