Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor

Table 1 Characteristics of patients n (%)

Characteristic	All patients (n = 1979)	Patients without infection (n = 937)	Patients with infection (n = 1042)	OR (95%CI)	P value
Age (yr), mean ± SD (range)	61 ± 16 (16-96)	61 ± 16 (16-96)	61 ± 16 (16-95)	1.003 (0.997-1.008)	> 0.20
Male sex	1236 (62.5)	614 (65.5)	622 (60)	0.779 (0.649-0.935)	0.0074
Days on ICU, mean ± SD (range)	5.53 ± 9.88 (1-217)	2.89 ± 5.97 (1-76)	8.12 ± 12 (1-217)	0.877 (0.858-0.897)	< 0.000001
Hospital-mortality	489 (24.7)	140 (14.9)	349 (33.5)	2.883 (2.312-3.595)	< 0.000001
Severity score on admission day
SAPS II, mean ± SD (range)	35 ± 16 (5-93)	30 ± 14 (5-80)	39 ± 16 (5-93)	0.958 (0.950-0.965)	< 0.000001
TISS, mean ± SD (range)	9.5 ± 8.8 (0-55)	6.3 ± 7.4 (0-35)	11.6 ± 9.1 (0-55)	0.925 (0.912-0.938)	< 0.000001
Highest severity score within 7 d after admission
SAPS II, mean ± SD (range)	39 ± 17 (6-93)	32 ± 15 (6-91)	44 ± 17 (6-93)	0.954 (0.947-0.961)	< 0.000001
TISS, mean ± SD (range)	12.0 ± 9.4 (0-55)	7.5 ± 8.0 (0-35)	14.6 ± 9.1 (0-55)	0.909 (0.897-0.921)	< 0.000001
Type of admission					< 0.000001
Internal medicine ICU	825 (41.7)	275 (29.3)	550 (52.8)
Cardiology ICU	1154 (58.3)	663 (70.8)	491 (47.1)
Source of admission					< 0.000001
Emergency department	923 (46.6)	468 (49.9)	455 (43.7)	Reference
Other hospital	274 (13.8)	87 (9.3)	187 (17.9)	2.211 (1.662-2.941)	< 0.000001
Hospital ward	613 (31.0)	276 (29.5)	337 (32.2)	1.256 (1.023-1.541)	0.029
Operating room	132 (67.0)	98 (10.5)	34 (3.3)	0.357 (0.237-0.538)	0.000001
Surgical IMC/ICU	38 (1.9)	9 (0.96)	29 (2.8)	3.314 (1.552-7.079)	0.0020
Comorbid conditions	1410 (71.2)	607 (64.8)	803 (77.1)	1.840 (1.511-2.241)	< 0.000001
COPD	233 (11.8)	84 (9.0)	149 (14.3)	1.696 (1.278-2.252)	0.00026
Heart failure (EF < 30%)	114 (5.8)	59 (6.3)	55 (5.3)	0.830 (0.569-1.212)	> 0.20
Coronary artery disease	455 (23.0)	244 (26.0)	211 (20.2)	0.722 (0.585-0.891)	0.0024
Chronic renal failure	342 (34.2)	140 (14.9)	202 (19.4)	1.371 (1.082-1.736)	0.0089
Diabetes mellitus	474 (24.0)	227 (24.2)	247 (23.7)	0.973 (0.791-1.197)	> 0.20
Liver-cirrhosis	175 (8.8)	57 (6.1)	118 (11.3)	1.974 (1.420-2.744)	0.000052
Cancer	229 (11.6)	89 (9.5)	140 (13.4)	1.481 (1.117-1.962)	0.0063
Hematologic neoplasia	111 (5.6)	39 (4.2)	72 (6.9)	1.711 (1.147-2.553)	0.0085
HIV	76 (3.8)	15 (1.6)	61 (5.9)	3.826 (2.160-6.779)	0.0000043
Immunosuppressive Tx	106 (5.4)	29 (3.1)	77 (7.4)	2.501 (1.616-3.870)	0.000039
Chemotherapy	108 (5.5)	32 (3.4)	76 (7.3)	2.230 (1.461-3.403)	0.00020
Number of cormobid conditions					0.000023
0	566 (28.6)	330 (35.2)	236 (22.6)
1	593 (30.0)	257 (27.4)	336 (32.2)
2	415 (21.0)	174 (18.6)	241 (23.1)
3	260 (13.1)	109 (11.6)	151 (14.5)
> 3	146 (7.4)	68 (7.3)	78 (7.5)
Mechanical ventilation	942 (47.6)	265 (28.3)	677 (65.0)	4.710 (3.892-5.701)	<0.000001
Hemodialysis	274 (13.8)	61 (6.5)	213 (20.4)	3.694 (2.736-4.987)	<0.000001

SAPS II: Simplified Acute Physiology Score II; TISS: Therapeutic Intervention Scoring System; ICU: Intensive care unit; IMC: Intermediate care unit, Internal Medicine ICU includes patients from Gastroenterology, Hepatology, Pulmonology, Endocrinology, Oncology, Hematology, Infectiology, Rheumatology departments, while Cardiology-ICU include patients from Cardiology, Angiology, Nephrology department; EF: Ejection fraction.