Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort

Table 5 Interaction analysis between rs17401966 and major environmental factors in hepatocellular carcinoma development

Variant and environmental factors		Cases	Controls	OR	95%CI	P value1	P value2
rs17401966 and alcohol drinking						0.038	0.102
AG + GG	No	69	91	1.00
AA	No	64	97	0.87	0.56-1.36
AG + GG	Yes	78	65	1.58	1.00-2.49
AA	Yes	95	53	2.36	1.49-3.74
rs17401966 and history of raw freshwater fish eating						0.470	0.852
AG + GG	No	53	88	1.00
AA	No	58	83	1.16	0.72-1.87
AG + GG	Yes	94	68	2.30	1.45-3.64
AA	Yes	101	67	2.50	1.58-3.96
rs17401966 and history of chronic hepatitis B virus infection						0.269	0.753
AG + GG	No	32	126	1.00
AA	No	45	126	1.41	0.84-2.36
AG + GG	Yes	115	30	15.09	8.63-26.39
AA	Yes	114	24	18.7	10.40-33.63
rs17401966 and family history of hepatoma						0.697	0.524
AG + GG	No	125	152	1.00
AA	No	128	142	1.10	0.78-1.53
AG + GG	Yes	22	4	6.69	2.25-19.92
AA	Yes	31	8	4.71	2.09-10.62

¹P values were calculated by test for additive interaction;

²P values were calculated by test for multiplicative interaction.