Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort

Table 4 Interaction analysis between rs3748578 and environmental factors in hepatocellular carcinoma development

Variant and environmental factors		Cases	Controls	OR	95%CI	P value1	P value2
rs3748578 and alcohol drinking						0.945	0.228
AG + AA	No	63	92	1.00
GG	No	70	96	1.06	0.68-1.66
AG + AA	Yes	74	64	1.69	1.06-2.68
GG	Yes	99	54	2.68	1.69-4.25
rs3748578 and history of raw freshwater fish eating						0.557	0.681
AG + AA	No	49	89	1.00
GG	No	62	82	1.37	0.85-2.22
AG + AA	Yes	88	67	2.39	1.49-3.82
GG	Yes	107	68	2.86	1.80-4.54
rs3748578 and history of chronic hepatitis B virus infection						0.850	0.815
AG + AA	No	30	126	1.00
GG	No	47	126	1.57	0.93-2.64
AG + AA	Yes	107	30	14.98	8.49-26.43
GG	Yes	122	24	21.35	11.82-38.58
rs3748578 and family history of HCC						0.372	0.555
AG + AA	No	117	152	1.00
GG	No	136	142	1.24	0.89-1.74
AG + AA	Yes	20	4	6.50	2.16-19.52
GG	Yes	33	8	5.36	2.39-12.04

¹P values were calculated by the test for additive interaction;

²P values were calculated by the test for multiplicative interaction.