Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort

Table 3 Association analysis between KIF1B variants and risk of hepatocellular carcinoma development n (%)

Variants	Crude OR (95%CI)	P value	Adjusted OR1 (95%CI)	P value1
rs3748578
GG	1.00		1.00
AG	0.74 (0.36-1.52)	0.411	0.71 (0.33-1.53)	0.380
AA	0.79 (0.57-1.09)	0.148	0.82 (0.58-1.62)	0.260
Dominant model	0.78 (0.57-1.07)	0.124	0.80 (0.57-1.13)	0.209
Recessive model	0.83 (0.41-1.67)	0.592	0.77 (0.36-1.65)	0.507
Additive model	0.82 (0.63-1.07)	0.137	0.83 (0.62-1.10)	0.193
rs17401966
AA	1.00		1.00
AG	0.86 (0.62-1.20)	0.374	0.86 (0.62-1.20)	0.379
GG	1.10 (0.56-2.15)	0.778	1.12 (0.57-2.21)	0.746
Dominant model	0.89 (0.65-1.22)	0.467	0.91 (0.64-1.27)	0.566
Recessive model	1.18 (0.62-2.26)	0.620	1.06 (0.52-2.15)	0.871
Additive model	0.95 (0.73-1.23)	0.692	0.94 (0.71-1.25)	0.685

¹The adjusted ORs, 95% confidence intervals (CIs) and their corresponding P values were calculated in a logistic regression model by adjusting for age, alcohol drinking, history of raw freshwater fish eating, history of chronic hepatitis B virus infection, family history of HBV infection, and family history of hepatoma.