Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort

Table 1 Distribution of selected characteristics and environmental factors in hepatocellular carcinoma cases and controls n (%)

Variable	Case (n = 306)	Control (n = 306)	P value	OR3	95%CI
Age, yr (mean ± SD)	55.84 ± 11.49	55.83 ± 11.67	0.9921
Sex
Male	264 (86.27)	264 (86.27)
Female	42 (13.73)	42 (13.73)	0.9982
Tobacco smoking
No	95 (31.05)	139 (45.42)
Yes	211 (68.95)	167 (54.58)	< 0.0142
Alcohol drinking
No	133 (43.46)	188 (38.56)		1.00	-
Yes	173 (56.54)	118 (61.44)	0.0122	2.45	1.24-4.82
History of raw freshwater fish eating
No	111 (36.27)	171 (55.88)		1.00	-
Yes	195 (63.73)	135 (44.12)	0.0302	1.99	1.06-3.75
Status of HBV infection
No	77 (25.16)	252 (82.35)		1.00	-
Yes	229 (74.84)	54 (17.65)	< 0.0132	12.02	6.02-24.00
Family history of HCC
No	256 (83.66)	294 (96.08)		1.00	-
Yes	50 (16.34)	12 (3.92)	< 0.0112	6.90	2.10-22.73

¹P value was calculated by the t test;

²P value was calculated by the χ² test;

³ORs were adjusted for age. HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; OR: Odds ratio.