Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model

doi:10.3748/wjg.v22.i16.4168

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World Journal of Gastroenterology

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World J Gastroenterol. Apr 28, 2016; 22(16): 4168-4182
Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4168

Table 7 Final reduced disease logistic predictive models based on binary classifier with the most significant markers (achieved regression P < 0.05)

	Final reduced model (with relevant terms)	Best threshold
Disease vs Control	(-11 + 6.83 × Prot + 0.00129 × sTNF + 0.283 × AFP)	0.764
HCC vs LC	(-11.3 + 7.38 × Prot + 0.00108 × sICAM + 0.2574 ×β-catenin + 0.01597 × AFP)	0.655
HCC vs HCV	[-11.91 + 3.222 × Prot + 0.001518 × sICAM + (6.481 × 10^-4) × sTNF + 0.291 ×β-catenin + 0.0193 × AFP]	0.712
HCC vs Non-HCC	[-12.27 + 3.299 × Prot + 0.001548 × sICAM + (6.803 × 10^-4) × sTNF + 0.2936 ×β-catenin + 0.0198 × AFP]	0.378
HCV vs Control	(-10.84 + 6.803 × Prot + 0.00126 × sTNF + 0.2783 × AFP)	0.764
LC vs CHC	[-10.16 + (-4.487) × Prot + 0.002086 × sICAM + 0.001858 × sTNF + (-0.2984) ×β-catenin + 0.02169 × AFP]	0.582
CHC vs Control	(-9.353476 + 6.63414 × Prot + 0.001111 × sTNF + 0.24604 × AFP)	0.341
HCC vs CHC	[-10.40 + 1.416 × Prot + 0.002024 × IL-8 + 0.004096 × sICAM + (4.251 × 10^-4) × sTNF + 0.2567 ×β-catenin + 0.02442 × AFP]	0.745

CHC: Chronic hepatitis C; LC: Liver cirrhosis; AFP: α-fetoprotein; HCC: Hepatocellular carcinoma; HCV: Hepatitis C virus.; sICAM-1: Soluble intercellular adhesion molecule; sTNF: Soluble tumor necrosis factor.

Citation: Zekri ARN, Youssef ASED, Bakr YM, Gabr RM, Ahmed OS, Elberry MH, Mayla AM, Abouelhoda M, Bahnassy AA. Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model. World J Gastroenterol 2016; 22(16): 4168-4182
URL: https://www.wjgnet.com/1007-9327/full/v22/i16/4168.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i16.4168