Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model

Table 6 Disease logistic predictive models based on binary-class classifier over different pairwise comparisons of the investigated groups

Combination	Model
Disease vs Control	[-11 + 6.83 × Prot + (-5.99 × 10-5) × IL-8 + 3.12 × 10-4× sICAM + 0.0013 × sTNF-RII + 0.172aβ-catenin + 0.283 × AFP][P values = 6.83E-10, 1.86E-05, 0.938962, 0.764414, 6.79E-08, 0.225761, 0.000818]
HCC vs LC	[11.33 + 7.380 × Prot + (-2.047 × 10-4) × IL-8 + 0.0011 × sICAM + 6.299 × 104× sTNF + 0.26 ×β-catenin + 0.016 × AFP][P values = 3.22E-05, 7.11E-07, 0.591834, 0.041838, 0.056595, 0.000357, 0.000638]
HCC vs HCV	[-11.9 + 3.222 × Prot + (3.813 × 10-4) × IL + 0.00152 × sICAM + (6.481 × 10-4) × sTNF + 0.0291 ×β-catenin + 0.019 × AFP][P values = 1.39E-11, 2.63E-12, 0.231248, 0.000928, 0.000952, 5.41E-06, 5.09E-06]
HCC vs Non-HCC	[-12.27 + 3.3 × Prot + 0.0004 × IL + 0.00155 × sICAM + (6.803 × 10-4) × sTNF + 0.294 ×β-catenin + 0.02 × AFP][P values = 5.26E-13, 4.14E-13, 0.211689, 0.000767, 0.000388, 3.89E-06, 3.42E-06]
HCV vs Control	[-10.84 + 6.80 × Prot + (2.68 × 10-5) × IL-8 + 0.00017 × ICAM + 0.00126 × sTNF + 0.1742 ×β-catenin + 0.278 × AFP][P values = 1.12E-09, 1.87E-05, 0.972804, 0.875503, 9.02E-08, 0.227858, 0.000935]
LC vs CHC	[-10.16 + (-4.487) × Prot + 0.00134 × IL-8 + 0.0021 × sICAM + 0.0018 × sTNF + (-0.2984) ×β-catenin + 0.0217 × AFP][P values = 0.002674, 0.000351, 0.052275., 0.021958, 0.000211, 0.009838, 0.030621]
CHC vs Control	[-9.354 + 6.634 × Proteasome + (-0.00166) × IL-8 + (-0.00126) × sICAM + 0.001111 × sTNF + 0.208624 ×β-catenin + 0.24604 × AFP][P values = 1.40E-07, 1.64E-05, 0.2627, 0.3799, 8.55E-06, 0.1477, 0.0016]
LC vs Control	[-515.7 + 108.7 × Proteasome + 0.01295 × IL-8 + 0.0194 × sICAM + 0.05745 × sTNF + 4.485 ×β-catenin + 12.59 × AFP][P values = 0.997, 0.998, 0.999, 0.999, 0.998, 0.998, 0.995]
HCC vs Control	[-375.640 + 122.598 × Prot + (-0.0577) × IL + 0.0368 × sICAM + 0.0427 × sTNF + 1.1533 ×β-catenin + 13.584 × AFP][P values = 0.737, 0.802, 0.823, 0.917, 0.812, 0.923, 0.66]
HCC vs CHC	[-10.40 + 1.416 × Prot + 0.002024 × IL-8 + 0.0041 × sICAM + (4.251 × 10-4) × sTNF + 0.2.67 ×β-catenin + 0.0244 × AFP][P values = 1.28E-07, 0.00826, 0.01827, 5.52E-05, 0.04942, 0.00391, 0.00354]

The values between brackets were the P values for the corresponding term parameter in the model respectively. Terms with P value < 0.05 are considered significant. The first P value was for overall model.