Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model

Table 4 Area under curve of individual markers vs combined one using (method 1 and 2) in different combinations of groups

	Method 1	Method 2	Proteasome	IL-8	sICAM-1	sTNF-RII	β-catenin	AFP
Disease vs Control	0.979	0.992	0.834	0.612	0.825	0.951	0.768	0.923
HCC vs LC	0.841	0.962	0.911	0.576	0.585	0.424	0.718	0.804
HCC vs HCV	0.866	0.952	0.799	0.639	0.705	0.568	0.723	0.849
HCC vs Non-HCC	0.917	0.970	0.848	0.652	0.787	0.724	0.771	0.902
HCV vs Control	0.957	0.983	0.726	0.543	0.716	0.928	0.677	0.850
LC vs CHC	0.695	0.951	0.220	0.648	0.769	0.829	0.494	0.736
CHC vs Control	0.917	0.968	0.846	0.471	0.571	0.857	0.678	0.749
LC vs Control	0.990	1.000	0.637	0.597	0.825	0.981	0.676	0.924
HCC vs Control	0.998	1.000	0.927	0.672	0.917	0.970	0.846	0.986
HCC vs CHC	0.967	0.971	0.648	0.724	0.867	0.762	0.730	0.908

Method 1 is based on multi-class classifier and Method 2 is based on binary-class classifier. HCV group: Include LC and CHC groups; Disease group: HCC, CHC and LC groups. CHC: Chronic hepatitis C; LC: Liver cirrhosis; AFP: α-fetoprotein; HCV: Hepatitis C virus.