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Copyright ©The Author(s) 2016.
World J Gastroenterol. Apr 21, 2016; 22(15): 3907-3936
Published online Apr 21, 2016. doi: 10.3748/wjg.v22.i15.3907
Table 2 miRNA observed deregulated in studies enrolling hepatocellular carcinoma patients with hepatitis B virus-related infection in at least three papers
miRNAType of deregulation(number of papers)Type of Sample(number of papers)Ref.
miR-221Upregulated (6)Tissue (5), serum (1)Gao P, Hepatology, 2011 Li J, Biochemical and Biophysical Research Communications, 2011 Li T, Oncology Reports, 2014 Li W, Int J Cancer, 2008 Wen Y, Int J Cancer, 2015 Zhang ZZ, WJG, 2011
1miR-21Upregulated (5)Tissue (4), serum (1)Bandopadhyay M, BMC Cancer, 2014 Connolly E, The American Journal of Pathology, 2008 Gao P, Hepatology, 2011 Li T, Oncology Reports, 2014 Xu J, Molecular Carcinogenesis, 2011
2miR-222Upregulated (4)Tissue (3), serum (1)Li W, Int J Cancer, 2008 Qi P, PLoS One, 2011 Zhang ZZ, WJG, 2011 Wen Y, Int J Cancer, 2015
3miR-122aUpregulated (4)Serum (4)Li LM, Cancer Research, 2010 Qi P, PLoS One, 2011 Xing TJ, Genetics and Molecular Research, 2014 Xu J, Molecular Carcinogenesis, 2011
miR-224Upregulated (4)Tissue (3), serum (1)Gao P, Hepatology, 2011 Gui J, Clinical Science, 2011 Li W, Int J Cancer, 2008 Zhang ZZ, WJG, 2011
4miR-101Downregulated (4)Tissue (4)Fu Y, Oncol Letters, 2013 Li W, Int J Cancer, 2008 Xie Y, Cancer Biology and Therapy, 2014 Zhang ZZ, WJG, 2011
miR-18aUpregulated (3)Tissue (2), serum (1)Li L, Digestive Diseases and Sciences, 2012 Li W, Int J Cancer, 2008 Zhang ZZ, WJG, 2011
miR-223Upregulated (3)Serum (3)Li LM, Cancer Research, 2010 Qi P, PLoS One, 2011 Xu J, Molecular Carcinogenesis, 2011
1miR-21: in one paper by Zhou [Zhou J, J Clin Oncol 2011] starting from serum samples, miR-21 was observed as down-regulated;
2miR-222: in one paper by Bandopadhyay [Bandopadhyay M, BMC Cancer 2014] starting from tissue samples, miR-222 was observed as down-regulated;
3miR-122a: in two papers by Tan et al and Zhou et al [Tan Y, PLoS One 2014; Zhou J, J Clin Oncol 2011] both starting from serum samples, miR-122 was observed as down-regulated;
4miR-101: in paper by Fu et al, miR-101 was observed as down-regulated in tissue but up-regulated in serum [Fu Y, Oncol Letters 2013].
  • Citation: Fiorino S, Bacchi-Reggiani ML, Visani M, Acquaviva G, Fornelli A, Masetti M, Tura A, Grizzi F, Zanello M, Mastrangelo L, Lombardi R, Di Tommaso L, Bondi A, Sabbatani S, Domanico A, Fabbri C, Leandri P, Pession A, Jovine E, de Biase D. MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis B- and C-related-hepatocellular-carcinoma. World J Gastroenterol 2016; 22(15): 3907-3936
  • URL: https://www.wjgnet.com/1007-9327/full/v22/i15/3907.htm
  • DOI: https://dx.doi.org/10.3748/wjg.v22.i15.3907