New treatment options for alcoholic hepatitis

Table 2 Ongoing registered studies on newer treatment for alcoholic hepatitis

Treatment	Type of molecule/intervention	Mechanism of action	Identifier
ELAD	Extracorporeal, human cell-based liver support system	Supplement hepatic function	NCT01829347, NCT00973817, NCT01471028
Obeticholic acid	Biliary acid	Affect bile acid abnormalities	NCT02039219
Corticosteroids + Bovine + Colostrum	Protein supplement	Improving immunity	NCT02473341
IMM 124-E	Hyperimmune bovine colostrum	Improving immunity	NCT01968382
G-CSF	Liver regeneration/immunomodulation	improves liver regeneration and immunity in steroid non-responders	NCT02442180, NCT02451033, NCT01820208
Corticosteroids + N-acetyl cysteine	Anti-oxidant	Augments steroid function	NCT00863785
Amoxicillin + corticosteroid	Antibiotic	Decreases infections	NCT02281929
S-adenosyl-l-methionine	Antioxidant	decreasing oxidative stress	NCT02024295
Rifaximin	Luminal antibiotic	Improves gut dysbiosis	NCT02116556, NCT02485106
Ciprofloxacin	Antibiotic	Decreasing infections	NCT02326103
Emricasan/IDN-6556	Pan-caspase inhibitor	Reduces apoptosis	NCT01912404
Lactobacillus Rhamnosus GG	Probiotic	Improving dysbiosis	NCT01922895
MycophenolateMofetil and Rilonacept	Immunosuppressant and immune modulation	Decreasing hepatic inflammation	NCT01903798
Metadoxine	Anti-oxidant		NCT02161653
Fecal microbiota transplantation	Healthy microbiome replacement	Correction of dysbiosis	NCT02458079
Early liver transplantation	New liver	Liver transplant in patients unresponsive to medical treatment	NCT01756794
Anakinra	interleukin-1 receptor antagonist	Decreases hepatic inflammation	NCT01809132