Multi-locus genetic risk score predicts risk for Crohn’s disease in Slovenian population

Figure 1 Area under curve for different P-values thresholds and corresponding numbers of included single nucleotide polymorphisms. The most optimal AUC was achieved with GRS of 33 risk alleles (AUC of 0.78) at P-value threshold of 0.256 (marked with *). Adding 41 SNPs to GRS did not improve GRS significantly, however it presented needless background noise. AUC: Area under curve; GRS: Genetic risk scores; SNPs: Single nucleotide polymorphisms.