Serrated colorectal cancer: Molecular classification, prognosis, and response to chemotherapy

Figure 2 Features of microvesicular hyperplastic polyps and goblet cell hyperplastic polyps. Microvesicular hyperplastic polyps (MVHPs) and goblet cell hyperplastic polyps (GCHPs) are premalignant lesions that differ mainly in their location and morphology. MVHPs are more likely to occur as a few large polyps in the ascendant colon, and GCHPs are more likely to occur as multiple small polyps in the left colon. Each can become senescent or evolve into another type of polyp. Although they can transform into other adenomas, MVHPs more often evolve into sessile serrated adenomas (SSAs), and GCHPs more often evolve into traditional serrated adenomas (TSAs). The prevalence of KRAS mutations is higher in TSAs, while BRAF mutations are more prevalent in SSAs.