Different risk factors for advanced colorectal neoplasm in young adults

Table 5 Multivariate analysis of risk factors for the development of advanced colorectal neoplasm in subjects over 50 according to sex

	n (%)	OR	95%CI	P value
Female (n = 4422)
Age	102/4422 (2.3)	1.04	1.01-1.08	0.006
Male (n = 6224)
Age	294/6224 (4.7)	1.09	1.07-1.11	< 0.001
Smoking
Never/former	188/4410 (4.3)		Reference
Current	106/1814 (5.8)	1.44	1.12-1.79	0.004
Obesity
No	164/3833 (4.3)		Reference
Yes	130/2391 (5.4)	1.41	1.11-1.79	0.005
CRC family history
No	281/5796 (4.8)		Reference
Yes	13/438 (3.0)	0.55	0.31-0.96	0.037
CEA	294/6224 (4.7)	1.04	1.01-1.08	0.023

Adjusted for age, smoking, alcohol, obesity (body mass index ≥ 25 kg/m²), triglyceride ≥ 150 mg/dL, HDL-C abnormality (HDL-C < 40 mg/dL for men or < 50 mg/dL for women), LDL-C, DM-R (fasting plasma glucose ≥ 100 mg/dL or hemoglobin A1c ≥ 6.5%, or use of diabetes medications), HTN-R (elevated blood pressure ≥ 130/85 mmHg or use of antihypertensive medications), insulin, regular exercise, CRC family history and CEA. OR: Odds ratio; CI: Confidence interval; CRC: Colorectal cancer; DM-R: Diabetes mellitus-related factors; HTN-R: Hypertension-related factors; CEA: Carcinoembryonic antigen; LDL-C: Low-density lipoprotein-cholesterol; HDL-C: High-density lipoprotein-cholesterol.