Different risk factors for advanced colorectal neoplasm in young adults

Table 4 Multivariate analysis of risk factors for the development of advanced colorectal neoplasm in subjects over 50

	n (%)	OR	95%CI	P value
Age	396/10646 (3.7)	1.08	1.06-1.09	< 0.001
Sex
Female	102/4422 (2.3)		Reference
Male	294/6224 (4.7)	2.12	1.68-2.68	< 0.001
Smoking
Never/former	261/7754 (3.4)		Reference
Current	135/2892 (4.7)	1.38	1.12-1.71	0.003
Obesity
No	229/6943 (3.3)		Reference
Yes	167/3703 (4.5)	1.34	1.09-1.65	0.005
CEA	396/10646 (3.7)	1.05	1.01-1.09	0.022

Adjusted for age, sex, smoking, alcohol, obesity (body mass index ≥ 25 kg/m²), triglyceride ≥ 150 mg/dL, HDL-C abnormality (HDL-C < 40 mg/dL for men or < 50 mg/dL for women), LDL-C, DM-R (fasting plasma glucose ≥ 100 mg/dL or hemoglobin A1c ≥ 6.5%, or use of diabetes medications), HTN-R (elevated blood pressure ≥ 130/85 mmHg or use of antihypertensive medications), insulin, regular exercise, CRC family history and CEA. OR: Odds ratio; CI: Confidence interval; CRC: Colorectal cancer; DM-R: Diabetes mellitus-related factors; HTN-R: Hypertension-related factors; CEA: Carcinoembryonic antigen; LDL-C: Low-density lipoprotein-cholesterol; HDL-C: High-density lipoprotein-cholesterol.