Different risk factors for advanced colorectal neoplasm in young adults

Table 3 Multivariate analysis of risk factors for the development of advanced colorectal neoplasm in subjects under 50 according to sex

	n (%)	OR	95%CI	P value
Female (n = 17138)
Age	123/17138 (0.7)	1.08	1.04-1.11	< 0.001
CEA	123/17138 (0.7)	1.12	1.02-1.23	0.023
Male (n = 42644)
Age	441/42644 (1.0)	1.09	1.07-1.10	< 0.001
Smoking
Never/former	255/29005 (0.9)		Reference
Current	186/13639 (1.4)	1.54	1.27-1.87	< 0.001
CRC family history
No	415/41174 (1.0)		Reference
Yes	26/1470 (1.8)	1.58	1.06-2.36	0.026
DM-R
No	300/32967 (0.9)		Reference
Yes	141/9677 (1.5)	1.34	1.09-1.65	0.005
Obesity
No	226/25027 (0.9)		Reference
Yes	215/17617 (1.2)	1.24	1.02-1.50	0.028
LDL-C	441/42644 (1.0)	1.01	1.01-1.02	0.008
CEA	441/42644 (1.0)	1.03	1.01-1.05	0.014

Adjusted for age, sex, smoking, alcohol, obesity (body mass index ≥ 25 kg/m²), abdominal obesity (waist circumference ≥ 90 cm for men or ≥ 85 cm for women), triglyceride ≥ 150 mg/dL, HDL-C abnormality (HDL-C < 40 mg/dL for men or < 50 mg/dL for women), LDL-C, DM-R (fasting plasma glucose ≥ 100 mg/dL or hemoglobin A1c ≥ 6.5%, or use of diabetes medications), HTN-R (elevated blood pressure ≥ 130/85 mmHg or use of antihypertensive medications), insulin, regular exercise, CRC family history and CEA. OR: Odds ratio; CI: Confidence interval; CRC: Colorectal cancer; DM-R: Diabetes mellitus-related factors; HTN-R: Hypertension-related factors; CEA: Carcinoembryonic antigen; LDL-C: Low-density lipoprotein-cholesterol; HDL-C: High-density lipoprotein-cholesterol.