Different risk factors for advanced colorectal neoplasm in young adults

Table 2 Multivariate analysis of risk factors for the development of advanced colorectal neoplasm in subjects under 50

	n (%)	OR	95%CI	P value
Age	564/59782 (0.9)	1.08	1.07-1.10	< 0.001
Sex
Female	123/17138 (0.7)		Reference
Male	441/42644 (1.0)	1.26	1.02-1.55	0.036
Smoking
Never/former	358/42681 (0.8)		Reference
Current	206/17101 (1.2)	1.37	1.15-1.63	< 0.001
CRC family history
No	533/57671 (0.9)		Reference
Yes	31/2111 (1.5)	1.46	1.01-2.10	0.044
DM-R
No	405/47799 (0.8)		Reference
Yes	159/11983 (1.3)	1.27	1.06-1.54	0.012
Obesity
No	327/39827 (0.8)		Reference
Yes	237/19955 (1.2)	1.23	1.03-1.47	0.021
LDL-C	564/59782 (0.9)	1.01	1.01-1.02	0.006
CEA	564/59782 (0.9)	1.04	1.01-1.09	0.031

Adjusted for age, sex, smoking, alcohol, obesity (body mass index ≥ 25 kg/m²), triglyceride ≥ 150 mg/dL, HDL-C abnormality (HDL-C < 40 mg/dL for men or < 50 mg/dL for women), LDL-C, DM-R (fasting plasma glucose ≥ 100 mg/dL or hemoglobin A1c ≥ 6.5%, or use of diabetes medications), HTN-R (elevated blood pressure ≥ 130/85 mmHg or use of antihypertensive medications), insulin, regular exercise, CRC family history and CEA. OR: Odds ratio; CI: Confidence interval; CRC: Colorectal cancer; DM-R: Diabetes mellitus-related factors; HTN-R: Hypertension-related factors; CEA: Carcinoembryonic antigen; LDL-C: Low-density lipoprotein-cholesterol; HDL-C: High-density lipoprotein-cholesterol.