Auphen and dibutyryl cAMP suppress growth of hepatocellular carcinoma by regulating expression of aquaporins 3 and 9 in vivo

Figure 3 Levels of AQP9 in hepatocellular carcinoma of different differentiation. A: Analysis of AQP9 protein expression by immunohistochemistry. a: AQP9 expression was high in normal liver samples; b: AQP9 expression was weak in well-differentiated HCC samples; c: AQP9 expression was high in normal liver samples; d: AQP9 expression was moderate in moderately differentiated HCC samples; e: AQP9 expression was high in normal liver samples; f: AQP9 expression was low in poorly differentiated HCC samples (magnification × 200, bar = 50 μm). B: The protein levels of AQP9 in HCC of different differentiation corresponded to their immunohistochemistry results: Tumor 1, well-differentiated HCC sample; tumor 2, moderately differentiated HCC sample; and tumor 3, poorly differentiated HCC sample. HCC: Hepatocellular carcinoma.