Auphen and dibutyryl cAMP suppress growth of hepatocellular carcinoma by regulating expression of aquaporins 3 and 9 in vivo

Figure 2 Levels of AQP3 in hepatocellular carcinoma of different differentiation. A: Analysis of AQP3 protein expression by immunohistochemistry. a: AQP3 expression decreased in normal liver tissues; b: AQP3 expression was weak in well-differentiated HCC samples; c: AQP3 expression decreased in normal liver tissues; d: AQP3 expression was moderate in moderately differentiated HCC samples; e: AQP3 expression decreased in normal liver samples; f: AQP3 expression was high in poorly differentiated HCC samples. B: The protein levels of AQP3 in HCC of different degrees of differentiation corresponded to their immunohistochemistry results. Tumor 1, well-differentiated HCC sample; tumor 2, moderately differentiated HCC sample; and tumor 3, poorly differentiated HCC sample. HCC: Hepatocellular carcinoma.