Glucose metabolic phenotype of pancreatic cancer

doi:10.3748/wjg.v22.i12.3471

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Mar 28, 2016; 22(12): 3471-3485
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3471

Table 5 Summary of changes in aerobic respiration in pancreatic ductal adenocarcinoma

Glycolytic Enzyme	Encoding gene	Change in PDAC	Implicated pathways	Known inhibitors	Inhibitor effect in PDAC
Pyruvate dehydrogenase complex	11p13		HIF-1	Dichloroacetate (inhibits PDC regulator, pyruvate dehydrogenase kinase)	Stimulates Krebs Cycle and reverses Warburg effect; Reduces PDAC proliferation and viability
Pyruvate dehydrogenase				Stimulator: Lipoic acid	Reduces cancer cell viability
Pyruvate dehydrogenase α	Xp22.1	Down
Pyruvate dehydrogenase β	3p21.1-p14.2	Down
Pyruvate carboxylase	11q13.4-q13.5	Up/down¹		Avidin
Citrate synthase	12q13.2	Up		Succinyl-CoA
Aconitase				Flouroacetate
Aconitase 1 (soluble)	9p21.1
Aconitase 2 (mitochondrial)	22q13.2	Down
Isocitrate dehydrogenase
ICD (soluble)	2q33.3
ICD (mitochondrial)	15q26.1	Down
Oxoglurate (α-ketoglutarate) Dehydrogenase	7p14-p13	Up
Succinyl-CoA synthetase		Down
Succinic dehydrogenase		Up/down¹
Fumarase	1q42.1			D-malic, trans-aconitic, citrate, glycine
Malate dehydrogenase
MD (soluble)	2p13.3
MD (mitochondrial)	7cen-q22	Up

¹Under-expressed in animal PDAC. PDAC: Pancreatic ductal adenocarcinoma.

Citation: Chan AK, Bruce JI, Siriwardena AK. Glucose metabolic phenotype of pancreatic cancer. World J Gastroenterol 2016; 22(12): 3471-3485
URL: https://www.wjgnet.com/1007-9327/full/v22/i12/3471.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i12.3471