Copyright
©The Author(s) 2016.
World J Gastroenterol. Mar 28, 2016; 22(12): 3471-3485
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3471
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3471
Table 5 Summary of changes in aerobic respiration in pancreatic ductal adenocarcinoma
| Glycolytic Enzyme | Encoding gene | Change in PDAC | Implicated pathways | Known inhibitors | Inhibitor effect in PDAC |
| Pyruvate dehydrogenase complex | 11p13 | HIF-1 | Dichloroacetate (inhibits PDC regulator, pyruvate dehydrogenase kinase) | Stimulates Krebs Cycle and reverses Warburg effect; Reduces PDAC proliferation and viability | |
| Pyruvate dehydrogenase | Stimulator: Lipoic acid | Reduces cancer cell viability | |||
| Pyruvate dehydrogenase α | Xp22.1 | Down | |||
| Pyruvate dehydrogenase β | 3p21.1-p14.2 | Down | |||
| Pyruvate carboxylase | 11q13.4-q13.5 | Up/down1 | Avidin | ||
| Citrate synthase | 12q13.2 | Up | Succinyl-CoA | ||
| Aconitase | Flouroacetate | ||||
| Aconitase 1 (soluble) | 9p21.1 | ||||
| Aconitase 2 (mitochondrial) | 22q13.2 | Down | |||
| Isocitrate dehydrogenase | |||||
| ICD (soluble) | 2q33.3 | ||||
| ICD (mitochondrial) | 15q26.1 | Down | |||
| Oxoglurate (α-ketoglutarate) Dehydrogenase | 7p14-p13 | Up | |||
| Succinyl-CoA synthetase | Down | ||||
| Succinic dehydrogenase | Up/down1 | ||||
| Fumarase | 1q42.1 | D-malic, trans-aconitic, citrate, glycine | |||
| Malate dehydrogenase | |||||
| MD (soluble) | 2p13.3 | ||||
| MD (mitochondrial) | 7cen-q22 | Up |
- Citation: Chan AK, Bruce JI, Siriwardena AK. Glucose metabolic phenotype of pancreatic cancer. World J Gastroenterol 2016; 22(12): 3471-3485
- URL: https://www.wjgnet.com/1007-9327/full/v22/i12/3471.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i12.3471