Daclatasvir vs telaprevir plus peginterferon alfa/ribavirin for hepatitis C virus genotype 1

doi:10.3748/wjg.v22.i12.3418

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2016; 22(12): 3418-3431
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3418

Table 3 Proportion of GT1b-infected patients with SVR12 by subgroups

SVR12¹, n/n (%)	*DCV + pegIFN/RBV(n =* 268)**	*TVR + pegIFN/RBV (n =* 134)**
Age (yr)
< 65	218/256 (85.2)	103/126 (81.7)
≥ 65	10/12 (83.3)	6/8 (75.0)
Sex
Male	134/159 (84.3)	61/72 (84.7)
Female	94/109 (86.2)	48/62 (77.4)
Race
White	208/243 (85.6)	105/129 (81.4)
Black/African American	11/16 (68.8)	2/3 (66.7)
Asian	6/6 (100.0)	2/2 (100.0)
Other	3/3 (100.0)	0
Baseline HCV-RNA
< 800000 IU/mL	66/72 (91.7)	33/37 (89.2)
≥ 800000 IU/mL	162/196 (82.7)	76/97 (78.4)
Cirrhosis
Absent	208/242 (86.0)	99/119 (83.2)
Present	20/26 (76.9)	10/15 (66.7)
IL28B genotype
CC	51/53 (96.2)	23/27 (85.2)
CT	132/161 (82.0)	69/86 (80.2)
TT	44/53 (83.0)	17/21 (81.0)

¹mITT analysis (patients with missing data at posttreatment week 12 were considered failures). DCV: Daclatasvir; GT: Genotype; HCV: Hepatitis C virus; pegIFN: Peginterferon alfa-2a; RBV: Ribavirin; SVR12: Sustained virologic response (HCV-RNA < LLOQ) at posttreatment week 12; TVR: Telaprevir.

Citation: Jacobson I, Zeuzem S, Flisiak R, Knysz B, Lueth S, Zarebska-Michaluk D, Janczewska E, Ferenci P, Diago M, Zignego AL, Safadi R, Baruch Y, Abdurakhmanov D, Shafran S, Thabut D, Bruck R, Gadano A, Thompson AJ, Kopit J, McPhee F, Michener T, Hughes EA, Yin PD, Noviello S. Daclatasvir vs telaprevir plus peginterferon alfa/ribavirin for hepatitis C virus genotype 1. World J Gastroenterol 2016; 22(12): 3418-3431
URL: https://www.wjgnet.com/1007-9327/full/v22/i12/3418.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i12.3418