Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan

Table 3 Odds ratio and 95%CI of two OGG1 single nucleotide polymorphisms for colorectal cancer stratified by sex, age at diagnosis, and tumor site and stage

	OGG1 Ser326Cys				OGG1 11657A/G
	Ser/Ser		Ser/Cys + Cys/Cys		A/A		A/G + G/G
	No.1	OR (95%CI)2	No.1	OR (95%CI)2	No.1	OR (95%CI)2	No.1	OR (95%CI)2
Gender
Male	50/67	1.00 (ref)	350/340	1.38 (0.93-2.05)	364/358	1.00 (ref)	31/47	0.65 (0.40-1.05)
Female	43/58	1.00 (ref)	271/265	1.38 (0.90-2.12)	284/296	1.00 (ref)	26/25	1.09 (0.61-1.93)
Age at diagnosis (yr)
≤ 60	44/54	1.00 (ref)	275/264	1.28 (0.83-1.97)	292/283	1.00 (ref)	23/32	0.70 (0.40-1.22)
> 60	49/71	1.00 (ref)	346/341	1.47 (0.99-2.17)	356/371	1.00 (ref)	34/40	0.89 (0.55-1.43)
Tumor site
Colon	45/125	1.00 (ref)	299/605	1.39 (0.96-2.01)	316/654	1.00 (ref)	23/72	0.67 (0.41-1.09)
Rectum	48/125	1.00 (ref)	322/605	1.39 (0.97-1.99)	332/654	1.00 (ref)	34/72	0.93 (0.61-1.43)
Stage
0, I, II	46/125	1.00 (ref)	283/605	1.28 (0.88-1.84)	307/654	1.00 (ref)	20/72	0.59 (0.35-0.98)a
III, IV	47/125	1.00 (ref)	338/605	1.48 (1.03-2.13)a	341/654	1.00 (ref)	37/72	0.99 (0.65-1.51)

¹Number of cases/number of controls;

²Adjustment for age and sex (except in gender stratification, where only sex was adjusted for). The

^aP < 0.05 is the comparison between CRC patients in stage 0, I, II and controls in calculating OR for A/G + G/G genotype vs A/A genotype.