Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan

Table 2 Distribution of OGG1 and APE1 polymorphisms between cases and controls n (%)

Genotype	Cases	Controls	OR (95%CI)1	P value
OGG1 Ser326Cys
Ser/Ser	93 (13.0)	125 (17.1)	1.00 (ref)
Ser/Cys	363 (50.8)	324 (44.4)	1.51 (1.11-2.05)	0.009
Cys/Cys	258 (36.1)	281 (38.5)	1.23 (0.90-1.69)	0.198
Ser/Cys + Cys/Cys	621 (87.0)	605 (82.9)	1.38 (1.03-1.85)	0.030
OGG1 11657A/G
A/A	648 (91.9)	654 (90.1)	1.00 (ref)
A/G	55 (7.8)	72 (9.9)	0.77 (0.53-1.12)	0.168
G/G	2 (0.3)	0 (0.0)	-
A/G + G/G	57 (8.1)	72 (9.9)	0.80 (0.56-1.15)	0.230
APE1 Asp148Glu
Asp/Asp	236 (33.0)	249 (34.3)	1.00 (ref)
Asp/Glu	349 (48.8)	361 (49.7)	1.02 (0.81-1.29)	0.864
Glu/Glu	130 (18.2)	117 (16.1)	1.17 (0.86-1.60)	0.308
Asp/Glu + Glu/Glu	479 (67.0)	478 (65.8)	1.06 (0.85-1.32)	0.615
APE1 T-656G
T/T	217 (30.1)	211 (28.9)	1.00 (ref)
T/G	368 (51.0)	380 (52.0)	0.94 (0.74-1.20)	0.630
G/G	136 (18.9)	140 (19.2)	0.95 (0.70-1.28)	0.731
T/G + G/G	504 (69.9)	520 (71.1)	0.95 (0.75-1.18)	0.621

¹ORs and 95%CIs were estimated from unconditional logistic regressions after controlling for age and sex.