Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan

Table 1 Age, sex, and genotype frequencies of the cases and controls n (%)

Variable	Cases	Controls	P value1
	n = 727	n = 736
Age (mean ± SD), yr	60.3 ± 12.8	60.7 ± 13.0	0.639
Gender			0.751
Male	410 (56.4)	409 (55.6)
Female	317 (43.6)	327 (44.4)
Colon/rectum, n	352/375
OGG1 Ser326Cys			0.021
Ser/Ser	93 (13.0)	125 (17.1)
Ser/Cys	363 (50.8)	324 (44.4)
Cys/Cys	258 (36.1)	281 (38.5)
Missing	13	6
OGG1 11657A/G			0.318
A/A	648 (91.9)	654 (90.1)
A/G	55 (7.8)	72 (9.9)
G/G	2 (0.3)	0 (0.0)
Missing	22	10
OGG1 Arg154His			0.158
Arg/Arg	720 (100.0)	720 (99.7)
Arg/His	0 (0.0)	2 (0.3)
His/His	0 (0.0)	0 (0.0)
Missing	7	14
APE1 Asp148Glu			0.567
Asp/Asp	236 (33.0)	249 (34.3)
Asp/Glu	349 (48.8)	361 (49.7)
Glu/Glu	130 (18.2)	117 (16.1)
Missing	12	9
APE1 T-656G			0.876
T/T	217 (30.1)	211 (28.9)
T/G	368 (51.0)	380 (52.0)
G/G	136 (18.9)	140 (19.2)
Missing	6	5

¹Continuous variables were tested by Student’s t-test, and categorical variables were tested by χ² or Mantel-Haenszel χ² test.