Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites

doi:10.3748/wjg.v22.i12.3363

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2016; 22(12): 3363-3371
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3363

Table 2 Body weight, vasopressin, and serum sodium in cirrhotic rats after tolvaptan (3 mg/kg), tolvaptan (5 mg/kg), or vehicle

		1 d	2 d	3 d	4 d	5 d
Body weight (g)	Vehicle	492.6 ± 11.22 (5)	498.5 ± 12.21 (5)	490.3 ± 16.21 (5)	500.1 ± 16.21 (5)	493.1 ± 11.12 (5)
	Tolvaptan (3 mg/kg)	482.2 ± 20.21 (5)	466.2 ± 10.19 (6)^a	450.1 ± 18.21 (5)^a	443.1 ± 20.12 (6)^a	440.1 ± 20.12 (5)^a
	Tolvaptan (5 mg/kg)	460.2 ± 12.31 (5)^a	455.1 ± 16.12 (5)^a	440.2 ± 23.12 (6)^a	437.3 ± 22.21 (5)^a	446.1 ± 21.21 (4)^a
Vasopressin (pg/L)	Vehicle	12.97 ± 0.92 (5)	13.81 ± 1.30 (5)	15.91 ± 0.89 (5)	16.97 ± 1.38 (5)	14.02 ± 0.98 (5)
	Tolvaptan (3 mg/kg)	12.25 ± 0.82 (5)	11.41 ± 0.62 (6)	10.21 ± 0.91 (5)^a	9.77 ± 1.21 (6)^a	7.12 ± 1.32 (5)^b
	Tolvaptan (5 mg/kg)	12.01 ± 1.21 (5)	10.12 ± 0.92 (5)^a	8.12 ± 1.22 (6)^a	7.01 ± 1.63 (5)^b	7.33 ± 1.13 (4)^a
Serum sodium (mol/L)	Vehicle	140.2 ± 1.25 (5)	140.2 ± 1.51 (5)	141.2 ± 0.65 (5)	141.1 ± 1.61 (5)	142.2 ± 0.81 (5)
	Tolvaptan (3 mg/kg)	143.2 ± 2.32 (5)	144.2 ± 1.17 (6)^a	146.1 ± 1.13 (5)^a	147.2 ± 2.11 (6)^b	146.1 ± 2.47 (5)^a
	Tolvaptan (5 mg/kg)	144.1 ± 1.22 (5)^a	147.1 ± 2.51 (5)^a	147.9 ± 2.21 (6)^a	146.2 ± 1.71 (5)^a	147.2 ± 1.12 (4)^b

Data are mean ± SEM (number of rats);

^aP < 0.05, tolvaptan vs vehicle, respectively;

^bP < 0.01, tolvaptan vs vehicle, respectively.

Citation: Chen C, Chen RP, Lin HH, Zhang WY, Huang XL, Huang ZM. Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites. World J Gastroenterol 2016; 22(12): 3363-3371
URL: https://www.wjgnet.com/1007-9327/full/v22/i12/3363.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i12.3363