Auphen and dibutyryl cAMP suppress growth of hepatocellular carcinoma by regulating expression of aquaporins 3 and 9 in vivo

Table 4 Cox regression analysis of patients with hepatocellular carcinoma

Variables	Univariate		P value
	HR	95%CI
AQP3 expression (1 = low, 2 = high)	4.948	1.037-23.605	0.045
AQP9 expression (1 = low, 2 = high)	10.835	1.488-78.877	0.019
Gender (1 = Male, 2 = Female)	2.681	0.852-8.436	0.092
Age (1 < 50, 2 ≥ 50)	2.579	0.332-20.049	0.365
Tumor size (1 < 5 cm, 2 ≥ 5)	1.261	0.334-4.759	0.732
Serum HBsAg (1 = Positive, 2= Negative)	0.575	0.153-2.154	0.411
Serum AFP (1 < 25 ng/mL, 2 ≥ 25 ng/mL)	1.102	0.293-4.146	0.886
Cirrhosis (1 = Presence, 2 = Absence)	1.401	0.373-5.268	0.618
UICC stage (1 = I + II, 2 = III + IV)	0.115	0.027-0.485	0.003
Metastasis/Recurrence (1 = Yes, 2 = No)	0.228	0.065-0.804	0.021
Edmondson grade [1 = Low (I/II), 2 = High (III/IV)]	0.560	0.175-1.791	0.328