Liver transplantation for hepatocellular carcinoma beyond the Milan criteria: A review

Table 2 Tumor markers and the cut-off of different selection criteria

Markers	Authors	Cut-off	Other content	Survival (5-yr)
				OS	RFS
AFP	Zheng et al[12]	AFP ≤ 400	Hangzhou criteria	78.3%	62.4%
	Toso et al[27]	AFP ≤ 400	Total tumor volume ≤ 115 cm3	None	None
	Wan et al[20]	AFP ≤ 400	Tumor ≤ 10 cm, no vascular and extrahepatic invasions	73.7%	74.4%
DCP	Ito et al[6]	DCP ≤ 400	Tumor size ≤ 10 cm	86.7%	None
	Soejima et al[13]	DCP ≤ 300	Tumor size ≤ 5 cm	None	93.8% (3-yr)
NLR	Xiao et al[43]	NLR < 4	None	61.5%	60.7%
AFP/CA199	Wan et al[30]	AFP ≤ 400, CA199 ≤ 400	None	74.6%	78.5%
NLR/CRP	Na et al[47]	NLR < 6.0 or CRP < 1.0	None	None	None
DCP/AFP	Todo et al[35]	DCP ≤ 100, AFP ≤ 200	Milan criteria	None	96.4%
	Shindoh et al[36]	AFP ≤ 250, DCP ≤ 450	Tokyo criteria	84.0%	96.8%

AFP: Alpha fetoprotein; DCP: Des-Gamma-carboxy prothrombin; NLR: Neutrophil-to-lymphocyte ratio; OS: Overall survival; RFS: Relapse free survival.