Melittin induces human gastric cancer cell apoptosis via activation of mitochondrial pathway

Figure 3 Melittin induced the apoptosis of SGC-7901 cells and increased the levels of reactive oxygen species. A: Melittin (4 μg/mL) induced the early apoptosis of SGC-7901 cells at different time points [a: SGC-7901 cells negative control group b: SGC-7901 cells incubated with 4 μg/mL melittin for 1 h; c: 4 SGC-7901 cells incubated with 4 μg/mL melittin for 2 h; d: SGC-7901 cells incubated with 4 μg/mL melittin for 4 h; (^aP < 0.05 vs the control group)]; B: The ROS levels in SGC-7901 cells after incubation with 4 μg/mL melittin. NC: SGC-7901 cells negative control group; PC: Positive control group; 1 h: SGC-7901 cells incubated with 4 μg/mL melittin for 1 h; 2 h: SGC-7901 cells incubated with 4 μg/mL melittin for 2 h; 4 h: SGC-7901 cells incubated with 4 μg/mL melittin for 4 h (^cP < 0.05 vs the control group).