Hepatitis B and D viruses replication interference: Influence of hepatitis B genotype

Table 1 Epidemiological and clinical profiles of patients included in the transversal study n (%)

	HBV	HBV + HIV	HBV + HDV	HBV + HDV + HIV
	(n = 27)	(n = 22)	(n = 31)	(n = 37)
Age (yr)1	38.54 ± 12.22	47.33 ± 8.50	41.15 ± 9.33	42.32 ± 7.76
Gender (M/F)	21/6	12/10	22/9	17/20
Caucasian	18 (67)	20 (91)	27 (87)	33 (89)
Subsaharian	9 (33)	2 (9)	4 (13)	4 (11)
ALT (IU/mL)1	66.58 ± 76.03c	70.67 ± 18.58	112.92 ± 84.39d	90.40 ± 21.92
AST (IU/mL)1	42.65 ± 27.76	32.67 ± 19.40	89.77 ± 62.43	38.33 ± 20.12
Anti-HCV	4 (15)	2 (9)	2 (6)	3 (8)
Anti-HBe	23 (85)	17 (77)	29 (93)	31 (84)
HBeAg	4 (15)	5 (23)	2 (7)	6 (16)
HBV genotype-A	17 (63)	12 (54)	12 (42)	16 (43)
HBV genotype-D	10 (37)	10 (46)	13 (42)	20 (54)
HBV genotype-E	0	0	4 (9)	1 (3)
HBV-DNA (Log10 IU/mL)2	3.90 (3.15-5.85)e	6.97 (5.58-7.25)f	1.58 (1.00-2.43)g	2.80 (1.00-7.02)
HBsAg (Log10 IU/mL)2	4.00 (3.81-4.22)h	5.46 (4.15-5.61)i	3.83 (3.59-4.39)j	3.83 (3.24-4.38)k
HDV-RNA (Log10 copies/mL)2	NA	NA	5.20 (4.37-5.74)	6.89 (4.41-7.73)

¹Data expressed as Mean ± SD;

²Data expressed as Median (IQR); c vs d: P = 0.043; e vs f: P = 0.007; f vs g: P = 0.037; h vs i: P = 0.001; j vs i and i vs k: P < 0.001. HBV genotypes data reported in this table has been obtained by commercial LIPA assay or using, in the negative cases, the PCR/sequencing method developed in this work. In two patients with CHD/HIV negative, the HBV genotype was not determined. HDV genotype 1 was found in the 60 Caucasian patients and in 6/8 (75%) of the immigrant Subsaharian patients. In the remaining 2 patients, HDV genotypes 3 and 4 were respectively detected, one of them infected with HBV-A and the other with HBV-D. In only 25 (37%) patients data about HBV/HDV coinfection date were available. No differences in the HBV duration of infection were observed between patients infected with HBV-A or HBV-D (mean ± SD: 21.5 ± 5.3 vs 23.75 ± 6.2 yr, respectively). HBV: Hepatitis B virus; HDV: Hepatitis delta virus; HIV: Human immunodeficiency virus; CHD: Chronic hepatitis delta; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.