Copyright
©The Author(s) 2016.
World J Gastroenterol. Mar 21, 2016; 22(11): 3078-3104
Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3078
Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3078
Table 4 Comparison of consequences of pediatric antibiotic-associated diarrhea vs adult antibiotic-associated diarrhea and pediatric Clostridium difficile infections vs adult Clostridium difficile infections
Pediatric AAD | Ref. | Adult AAD | Ref. | Pediatric CDI | Ref. | Adult CDI | Ref. | |
Premature stop of antibiotic therapy | Yes | Damrongmanee[76] | 4% | Elseviers[37] | NR | NR | ||
Dehydration | NR | 17% | Elseviers[37] | 75% | Duleba[18] | NR | ||
Attributable mortality | NR | NR | 2% | Despandi[169] | 5.7% | Dubberke[213] | ||
2.2% | Sammons[44] | 5.7% | Gravel[119] | |||||
3% | de Blank[69] | 4.5% | Tabak[117] | |||||
6.3% | Vesteinsdottir[73] | |||||||
6.9% | Loo[57] | |||||||
15% | McFarland[121] | |||||||
17% | Pépin[58] | |||||||
Crude mortality | NR | 3.6% | Selinger[112] | 1% | Morinville[100] | 10% | Tabak[117] | |
2% | Nylund[14] | 16.5% | Wenisch[102] | |||||
3.8% | Kim[115] | 28% | Bacci[120] | |||||
4.6% | Crews[12] | 35% | Eyre[118] | |||||
5% | de Blank[69] | 38% | Dubberke[213] | |||||
5.4% | Pai[71] | |||||||
Colectomy | NR | NR | 0.1% | Wendt[4] | 0.3% | See[107] | ||
0.9% | Despandi[169] | 0.7% | Halabi[214] | |||||
0.9% | Nylund[14] | 1.2% | Dallal[108] | |||||
1% | Pai[71] | 2% | McFarland[121] | |||||
1.2% | Kim[115] | 6.2% | Muto[59] | |||||
9.1% | Jarvis[175] | |||||||
Cost | NR | $1400 | Song[113] | $18900-$93000 | Sammons[44] | $3103 | McFarland[89] | |
($/patient) | $1968 | Kamdeu[215] | $28404 | Despande[169] | $3427-$33055 | Kwon[10] | ||
$31957 | Nylund[14] | $3427-99601 | Dubberke[216] | |||||
$7179 | Dubberke[217] | |||||||
$116312 | Dubberke[216] | |||||||
$113533 | Lawrence[124] | |||||||
$23643 | Tabak[117] | |||||||
Length of stay (days additional stay) | NR | 8.5 d | Elseviers[37] | 4 d | Despande[169] | 3 d | Lawrence[124] | |
4 d | Nylund[14] | 4 d | Dubberke[217] | |||||
6 d | Sammons[44] | 6 d | Vesteinsdottir[73] | |||||
23d | de Blank[69] | 10 d | Abdelsattar[218] | |||||
13 d | Tabak[117] | |||||||
14 d | Crabtree[184] | |||||||
16 d | Zerey[193] | |||||||
24 d | McFarland[121] | |||||||
Re-admissions | NR | 8% | Pozzoni[160] | NR | 21% | McFarland[121] | ||
39% | Abdelsattar[218] | |||||||
52% | Dubberke[213] |
- Citation: McFarland LV, Ozen M, Dinleyici EC, Goh S. Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections. World J Gastroenterol 2016; 22(11): 3078-3104
- URL: https://www.wjgnet.com/1007-9327/full/v22/i11/3078.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i11.3078