Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression

Figure 5 Effect of fenofibrate (100 mg/kg) and resveratrol (70 mg/kg) alone and in combination (half doses) on serum AST (A), ALT (B), AST/ALT ratio (C) and serum TNF-α (D) in fructose-induced NASH in rats. Values are mean ± SE, n = 8-12 rats. The significance of the difference between means was tested by ANOVA followed by Tukey Kramer multiple comparisons test. ^aP < 0.05 vs control; ^bP < 0.05 vs FED; ^cP < 0.05 vs FENO. FED: Fructose enriched diet; FENO: Fenofibrate; RES: Resveratrol; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; TNF-α: Tumor necrosis factor-α.