Factors associated with increased incidence of severe toxicities following yttrium-90 resin microspheres in the treatment of hepatic malignancies

Table 3 Severe toxicity incidence

Severe toxicities	Our patients		Time to toxicity development			Literature
	n	%	mean ± SD	range	Number of resolved1
Any	17	21.5				7%-38%[7,9,39]
INR	1	1.4	25.00 ± 0.00		0	1.3%-1.8%[20,27]
Albumin	10	12.7	97.80 ± 40.59	(35-174)		0%-2%[9,27,40]
AST	2	2.5	98.00 ± 19.80	(84-112)	0	0%-8%[7,9,20,22,23,27,40]
ALT	0	0.0
ALP	14	17.7	86.46 ± 58.37	(3-182)	5	0.5%-20%[7,9,20,23,40]
Total bilirubin	8	10.1	80.75 ± 51.63	(14-182)	1	0%-27%[7,9,20,22,23,27,40]

¹Toxicities were considered irreversible if values remained grade ≥ 3 until last recorded measurement. INR: International normalized ratio; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase.