Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population

Table 5 Risk factors of colorectal advanced adenoma in young subjects n (%)

Variable	Number of persons		Univariate analysis		Multivariate analysis1
	Non-advanced adenoma	Advanced adenoma	OR (95%CI)	P value	OR (95%CI)	P value
	(n = 1760)	(n = 16)
Males	1258 (71.5)	13 (81.3)	1.73 (0.49-6.09)	0.388
Age (yr)
45-49	485 (27.6)	6 (37.5)	1	0.570
40-44	587 (33.4)	4 (25.0)	0.55 (0.16-1.96)
< 40	688 (39.1)	6 (37.5)	0.71 (0.23-2.20)
Body mass index (kg/m2)
mean ± SD	23.6 ± 3.2	24.8 ± 2.8
< 25	79 (4.5)	0 (0.0)	1	0.862
25.0-29.9	492 (28.0)	4 (25.0)	1.66 (1.25-2.20)
≥ 30	63 (3.6)	1 (6.3)	1.16 (0.56-2.40)
Waist circumference (cm)
mean ± SD	82.5 ± 9.7	86.1 ± 6.6
Male < 90, female < 80	1313 (74.6)	12 (75.0)	1	0.971
Male ≥ 90, female ≥ 80	447 (25.4)	4 (25.0)	0.98 (0.31-3.05)
Diabetes mellitus	70 (4.0)	1 (6.3)	1.61 (0.21-12.36)	0.644
Hypertension	388 (22.0)	2 (12.5)	0.51 (0.11-2.23)	0.359
Metabolic syndrome	191 (10.9)	1 (6.3)	0.55 (0.07-4.17)	0.555
High hsCRP
mean ± SD	148 (8.4)	2 (12.5)
< 0.10	1149 (65.3)	11 (68.8)	1	0.772
≥ 0.10	611 (34.7)	5 (31.3)	0.86 (0.30-2.47)
Triglyceride (mg/dL)
mean ± SD	123.0 ± 89.3	121.1 ± 72.3
< 150	1321 (75.1)	12 (75.0)	1	0.996
≥ 150	439 (24.9)	4 (25.0)	1.00 (0.32-3.13)
HDL cholesterol (mg/dL)
mean ± SD	57.6 ± 14.8	60.1 ± 19.3
Male < 40, female < 50	191 (10.9)	1 (6.3)	1	0.555
Male ≥ 40, female ≥ 50	1569 (89.1)	15 (93.8)	1.83 (0.24-13.90)
LDL cholesterol (mg/dL)
mean ± SD	135.5 ± 41.9	139.1 ± 43.9
≤ 100	278 (15.8)	4 (25.0)	1	0.703
101-129	559 (31.8)	1 (6.3)	0.12 (0.01-1.12)
≥ 130	923 (52.4)	11 (68.8)	0.83 (0.26-2.62)
Total cholesterol (mg/dL)
mean ± SD	206.4 ± 38.3	214.1 ± 41.3
< 200	810 (46.0)	5 (31.3)	1	0.238
≥ 200	950 (54.0)	11 (68.8)	1.88 (0.65-5.42)
Current alcohol	758 (43.1)	12 (75.0)	3.97 (1.27-12.34)	0.010	3.69 (1.08-12.54)	0.037
Smoking status
Never	701 (39.8)	4 (25.0)	1	0.129	1
Former	398 (22.6)	3 (18.8)	1.32 (0.29-5.93)		0.81 (0.17-3.86)	0.789
Current	661 (37.6)	9 (56.3)	2.39 (0.73-7.79)		1.38 (0.39-4.93)	0.620

¹Adjusted for alcohol and smoking. hsCRP: High-sensitivity C-reactive protein; HDL: High-density lipoprotein cholesterol; LDL: Low-density lipoprotein cholesterol.