Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population

Table 3 Risk factors of colorectal advanced adenoma in this study population n (%)

Variable	Number of persons		Univariate analysis		Multivariate analysis1
	Non-advanced adenoma	Advanced adenoma	OR (95%CI)	P value	OR (95%CI)	P value
	(n = 2778)	(n = 41)
Males	1955 (70.4)	33 (80.5)	1.74 (0.80-3.78)	0.159	0.80 (0.27-2.43)	0.697
Age (yr)
≥ 50	1018 (36.6)	25 (61.0)	1	0.003	1
45-49	485 (17.5)	6 (14.6)	0.50 (0.21-1.24)		0.43 (0.17-1.07)	0.070
40-44	587 (21.1)	4 (9.8)	0.28 (0.10-0.80)		0.24 (0.08-0.71)	0.010
< 40	688 (24.8)	6 (14.6)	0.36 (0.15-0.87)		0.34 (0.13-0.85)	0.022
Body mass index (kg/m2)
mean ± SD	23.7 ± 3.1	24.5 ± 3.0
< 25	1764 (63.5)	25 (61.0)	1	0.518
25.0-29.9	814 (29.3)	13 (31.7)	1.15 (0.59-2.25)
≥ 30	92 (3.3)	2 (4.9)	1.57 (0.37-6.70)
Waist circumference (cm)
mean ± SD	83.1 ± 9.4	85.9 ± 7.1
Male < 90, female < 80	1985 (71.5)	26 (63.4)	1	0.258
Male ≥ 90, female ≥ 80	793 (28.5)	15 (36.6)	1.44 (0.76-2.74)
Diabetes mellitus	196 (7.1)	5 (12.2)	1.83 (0.71-4.72)	0.204
Hypertension	835 (30.1)	17 (41.5)	1.65 (0.88-3.08)	0.114	1.03 (0.45-2.38)	0.947
Metabolic syndrome	409 (14.7)	9 (22.0)	1.63 (0.77-3.44)	0.196	1.06 (0.40-2.80)	0.907
hsCRP (mg/dL)
< 0.10	1747 (62.9)	24 (58.5)	1	0.567
≥ 0.10	1031 (37.1)	17 (41.5)	1.20 (0.64-2.25)
Triglyceride (mg/dL)
mean ± SD	123.1 ± 87.3	136.8 ± 75.3
< 150	2091 (75.3)	27 (65.9)	1	0.166	1
≥ 150	687 (24.7)	14 (34.1)	1.58 (0.82-3.03)		1.23 (0.62-2.45)	0.555
HDL cholesterol (mg/dL)
mean ± SD	57.3 ± 15.0	56.2 ± 15.7
Male < 40, female < 50	348 (12.5)	6 (14.6)	1	0.686
Male ≥ 40, female ≥ 50	2430 (87.5)	35 (85.4)	0.84 (0.35-2.00)
LDL cholesterol (mg/dL)
mean ± SD	136.3 ± 39.4	137.2 ± 46.3
≤ 100	423 (15.2)	7 (17.1)	1	0.876
101-129	840 (30.2)	11 (26.8)	0.79 (0.31-2.06)
≥ 130	1515 (54.5)	23 (56.1)	0.92 (0.39-2.15)
Total cholesterol (mg/dL)
mean ± SD	207.1 ± 38.5	208.7 ± 52.1
< 200	1240 (44.6)	19 (46.3)	1	0.827
≥ 200	1538 (55.4)	22 (53.7)	0.93 (0.50-1.73)
Current alcohol	1093 (39.3)	25 (61.0)	2.41 (1.28-4.53)	0.005	2.39 (1.14-4.99)	0.021
Smoking status
Never	1143 (41.1)	11 (26.8)	1	0.106	1
Former	753 (27.1)	14 (34.1)	1.93 (0.87-4.28)		1.40 (0.50-3.92)	0.516
Current	882 (31.7)	16 (39.0)	1.89 (0.87-4.08)		1.61 (0.58-4.45)	0.363

¹Adjusted for sex, age, hypertension, metabolic syndrome, triglyceride, alcohol, and smoking. hsCRP: High-sensitivity C-reactive protein; HDL: High-density lipoprotein cholesterol; LDL: Low-density lipoprotein cholesterol.