Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population

Table 2 Risk factors of colorectal adenoma in this study population n (%)

Variable	Number of persons		Univariate analysis		Multivariate analysis1
	Non-adenoma	Adenoma	OR (95%CI)	P value	OR (95%CI)	P value
	(n = 2264)	(n = 555)
Males	1530 (67.6)	458 (82.5)	2.27 (1.79-2.87)	< 0.001	1.88 (1.35-2.61)	< 0.001
Age (yr)
≥ 50	741 (32.7)	302 (54.4)	1	< 0.001	1
45-49	386 (17.0)	105 (18.9)	0.67 (0.52-0.86)		0.64 (0.49-0.84)	0.001
40-44	504 (22.3)	87 (15.7)	0.42 (0.33-0.55)		0.40 (0.30-0.53)	< 0.001
< 40	633 (28.0)	61 (11.0)	0.24 (0.18-0.32)		0.25 (0.18-0.34)	< 0.001
Body mass index (kg/m2)
mean ± SD	23.6 ± 3.2	24.4 ± 3.0
< 25	1468 (64.8)	321 (57.8)	1	< 0.001	1
25.0-29.9	624 (27.6)	203 (36.6)	1.52 (1.25-1.86)		0.94 (0.72-1.23)	0.644
≥ 30	76 (3.4)	18 (3.2)	1.11 (0.65-1.88)		0.68 (0.37-1.24)	0.204
Waist circumference (cm)
mean ± SD	82.6 ± 9.4	85.5 ± 8.7
Male < 90, female < 80	1658 (73.2)	353 (63.6)	1	< 0.001	1
Male ≥ 90, female ≥ 80	606 (6.8)	202 (36.4)	1.57 (1.28-1.91)		1.50 (1.14-1.97)	0.004
Diabetes mellitus	144 (6.4)	57 (10.3)	1.69 (1.22-2.33)	0.001	1.12 (0.79-1.57)	0.533
Hypertension	623 (27.5)	229 (41.3)	1.85 (1.53-2.24)	< 0.001	1.27 (0.96-1.67)	0.095
Metabolic syndrome	308 (13.6)	110 (19.8)	1.57 (1.23-2.00)	< 0.001	0.86 (0.59-1.26)	0.445
hsCRP
< 0.10			1	0.020	1
≥ 0.10			1.25 (1.04-1.51)		1.05 (0.82-1.34)	0.725
Triglyceride (mg/dL)
mean ± SD	119.7 ± 85.8	138.1 ± 91.0
< 150	1742 (76.9)	376 (67.7)	1	< 0.001	1
≥ 150	522 (23.1)	179 (32.3)	1.59 (1.30-1.95)		1.15 (0.92-1.45)	0.227
HDL cholesterol (mg/dL)
mean ± SD	57.9 ± 15.0	54.9 ± 14.6
Male < 40, female < 50	277 (12.2)	77 (13.9)	1	0.296
Male ≥ 40, female ≥ 50	1987 (87.8)	478 (86.1)	0.87 (0.66-1.14)
LDL cholesterol (mg/dL)
mean ± SD	135.7 ± 40.3	138.5 ± 36.1
≤ 100	354 (15.6)	76 (13.7)	1	0.070
101-129	699 (30.9)	152 (27.4)	1.01 (0.75-1.37)
≥ 130	1211 (53.5)	327 (58.9)	1.26 (0.95-1.66)
Total cholesterol (mg/dL)
mean ± SD	206.7 ± 38.5	209.0 ± 40.0
< 200	1033 (45.6)	226 (40.7)	1	0.037	1
≥ 200	1231 (54.4)	329 (59.3)	1.22 (1.01-1.48)		1.09 (0.89-1.34)	0.390
Current alcohol	871 (38.5)	247 (44.5)	1.28 (1.06-1.55)	0.009	0.93 (0.75-1.16)	0.513
Smoking status
Never	994 (43.9)	160 (28.8)	1	< 0.001	1
Former	584 (25.8)	18 (33.0)	1.90 (1.54-2.46)		1.21 (0.90-1.63)	0.215
Current	68 (30.3)	21(38.2)	1.90 (1.53-2.41)		1.56 (1.16-2.10)	0.003

¹Adjusted for sex, age, body mass index, waist circumference, diabetes mellitus, hypertension, metabolic syndrome, hsCRP, triglyceride, alcohol, and smoking. hsCRP: High-sensitivity C-reactive protein; HDL: High-density lipoprotein cholesterol; LDL: Low-density lipoprotein cholesterol.