Xenobiotics and loss of tolerance in primary biliary cholangitis

doi:10.3748/wjg.v22.i1.338

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 7, 2016; 22(1): 338-348
Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.338

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Figure 3 APAP metabolism and proposed mechanism of APAP-mediated breaking of immune tolerance. APAP is metabolized in the liver to nontoxic compounds via conjugation of the aromatic ring to sulfate or glucuronic acid. APAP is converted into a highly electrophilic metabolite, NAPQI by microsomal cytochrome P450 oxidation. Reactive NAPQI accumulates and can form adducts with cellular proteins, leading to disruption of cellular functions, generation of neo-antigens, and loss of tolerance.

Citation: Wang J, Yang G, Dubrovsky AM, Choi J, Leung PS. Xenobiotics and loss of tolerance in primary biliary cholangitis. World J Gastroenterol 2016; 22(1): 338-348
URL: https://www.wjgnet.com/1007-9327/full/v22/i1/338.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i1.338