Copyright
©The Author(s) 2016.
World J Gastroenterol. Jan 7, 2016; 22(1): 275-283
Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.275
Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.275
Figure 2 Possible roles of glypican-3 in progression of hepatocellular carcinoma.
Cell surface glypican-3 (GPC3) forms a complex with Wnt and heparin-binding growth factors such as fibroblast growth factor (FGF) and hepatocyte growth factor (HGF) via its heparan sulfate (HS) side chains and stimulates receptor-mediated signaling in hepatocellular carcinoma (HCC) cells. SULF2 expressed in HCC cells cleaves the HS to release these ligands from the GPC3/ligand complex, which may also upregulate signaling in neighboring HCC cells.
- Citation: Haruyama Y, Kataoka H. Glypican-3 is a prognostic factor and an immunotherapeutic target in hepatocellular carcinoma. World J Gastroenterol 2016; 22(1): 275-283
- URL: https://www.wjgnet.com/1007-9327/full/v22/i1/275.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i1.275