Autophagy and microRNA in hepatitis B virus-related hepatocellular carcinoma

doi:10.3748/wjg.v22.i1.176

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 7, 2016; 22(1): 176-187
Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.176

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Figure 4 Hepatitis B virus regulates microRNAs biogenesis. Hepatitis B virus (HBV) regulates the biogenesis of miRNA by affecting the miRNA-related Rnases. HBx protein downregulates Drosha expression through reduction of the transcriptional activity of Drosha promoter and upregulates the expression of transcription factor YY1 to suppress DGCR8 expression by repressing DGCR8 promoter activity. Single nucleotide polymorphisms (SNPs) located on 3’UTR of Dicer and RAN genes affect the biogenesis of miRNA in HBV-related diseases. DGCR8: DiGeorge syndrome critical region gene 8.

Citation: Wu SY, Lan SH, Liu HS. Autophagy and microRNA in hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2016; 22(1): 176-187
URL: https://www.wjgnet.com/1007-9327/full/v22/i1/176.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i1.176