Autophagy and microRNA in hepatitis B virus-related hepatocellular carcinoma

Figure 3 Hepatitis B virus affects microRNA transcription and stability. Hepatitis B virus (HBV) suppresses miR-122 through different mechanisms. A: HBV suppresses miR-122 promoter activity and expression through transcriptional regulation by directly interacting with peroxisome proliferator activated receptor-gamma (PPARγ); B: HBx suppresses transcription of Gld2 to decrease miR-122 stability; and C: HBV functions as a sponge to bind miR-122 and reduces its expression. RXRa: Retinoid X Receptor, Alpha; Gld2: Germline development 2.