Distinctive aspects of peptic ulcer disease, Dieulafoy's lesion, and Mallory-Weiss syndrome in patients with advanced alcoholic liver disease or cirrhosis

Table 10 Efficacy of endoscopic therapy for gastrointestinal bleeding from Mallory-Weiss syndrome in cirrhotics

Number of patients	HemostasisTechnique	n (%) with active alcohol abuse	Time of EGD	Study type	Follow-up	Outcome	Ref.
55	Aetoxysklerol injection	40 (73)	Within 6 h	Retrospective	2 yr	No rebleeding or death	Paquet et al[26]
141	Epinephrine injection/elec-trocoagulation	6 (43)	Within 24 h	Retrospective	5 yr	No rebleeding or death2	Schuman et al[27]
7	Band ligation 4	Not reported	Within 12 h	Retrospective	5 d	No rebleeding or death	Lecleire et al[165]
	Hemoclips and epinephrine 3
3	Heater probe/Bicap electrocoagulation	3 (100)	“Urgently” after presentation	Retrospective	17 mo	Failed to control bleeding in 1/3 pts (33%)	Jensen et al[28]
1	Hemoclip and Endoscopic band ligation	1 (100)	“Emergent-ly” at presentation	Retrospective	NA	Failed to stop bleeding with both techniques; patient underwent surgery and died of liver failure 3 d after surgery	Yin et al[104]

¹Only 3 of the 14 patients treated endoscopically;

²Three deaths reported out of the overall cohort of 42 patients presenting with bleeding from MWS. None of the deaths were related to MWS or liver disease. EGD: Esophagogastroduodenoscopy; MWS: Mallory-Weiss syndrome.