Xenobiotics and loss of tolerance in primary biliary cholangitis

doi:10.3748/wjg.v22.i1.338

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 7, 2016; 22(1): 338-348
Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.338

Table 2 Influence of Th1 and Th17 cytokine in liver pathology of 2OA-BSA induced primary biliary cholangitis mouse model

Pathway	Cytokine k/o	Liver pathology
Th1	IL-12p35^-/-	Reduced liver infiltrates, reduced bile duct damage
Th1	IFN-γ^-/-	Marked reduction in liver infiltrates, bile duct normal
Th1/Th17	IL-12/IL-23p40^-/-	Abolish autoimmune cholangitis
Th17	IL-23p19^-/-	Reduced liver infiltrates, reduced bile duct damage
Th17	IL-17A^-/-	Reduced liver infiltrates, reduced bile duct damage
Th17	IL-17F^-/-	Similar to positive control
Th17	IL-22^-/-	Reduced liver infiltrates, reduced bile duct damage

IFN-γ: Interferon-γ; IL: Interleukin; Th17: T helper 17.

Citation: Wang J, Yang G, Dubrovsky AM, Choi J, Leung PS. Xenobiotics and loss of tolerance in primary biliary cholangitis. World J Gastroenterol 2016; 22(1): 338-348
URL: https://www.wjgnet.com/1007-9327/full/v22/i1/338.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i1.338