Xenobiotics and loss of tolerance in primary biliary cholangitis

doi:10.3748/wjg.v22.i1.338

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 22, Issue 1

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7611)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-2) series.

Item

Count

PDF

668

WORD

322

HTML

4600

Figures (1-3)

226

Tables (1-2)

174

Sum=5990

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

752

Download

869

Sum=1621

Jan 7, 2016 (publication date) through Jul 25, 2024

Times Cited of This Article

Times Cited (14)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Gastroenterol. Jan 7, 2016; 22(1): 338-348
Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.338

Table 2 Influence of Th1 and Th17 cytokine in liver pathology of 2OA-BSA induced primary biliary cholangitis mouse model

Pathway	Cytokine k/o	Liver pathology
Th1	IL-12p35^-/-	Reduced liver infiltrates, reduced bile duct damage
Th1	IFN-γ^-/-	Marked reduction in liver infiltrates, bile duct normal
Th1/Th17	IL-12/IL-23p40^-/-	Abolish autoimmune cholangitis
Th17	IL-23p19^-/-	Reduced liver infiltrates, reduced bile duct damage
Th17	IL-17A^-/-	Reduced liver infiltrates, reduced bile duct damage
Th17	IL-17F^-/-	Similar to positive control
Th17	IL-22^-/-	Reduced liver infiltrates, reduced bile duct damage

IFN-γ: Interferon-γ; IL: Interleukin; Th17: T helper 17.

Citation: Wang J, Yang G, Dubrovsky AM, Choi J, Leung PS. Xenobiotics and loss of tolerance in primary biliary cholangitis. World J Gastroenterol 2016; 22(1): 338-348
URL: https://www.wjgnet.com/1007-9327/full/v22/i1/338.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i1.338