Overview of hepatitis B virus mutations and their implications in the management of infection

doi:10.3748/wjg.v22.i1.145

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jan 7, 2016; 22(1): 145-154
Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.145

Table 2 Impact of drug resistant mutations in the the hepatitis B virus Pol on the hepatitis B surface antigen

Antiviral drugs	Resistance mutations	HBsAg correspondingchanges
Lamivudine (LAM²) Tebivudine (LdT²)	rtL180M	No change
	rtM204V	sI195M
	rtM204I²	sW196¹/S/L
Adefovir (AdV) Tenofovir (TDF) LAM²	rtA181T²	sW172¹
	rtA181T²	sW172L
	rtA181V²	sL173F
	rtN236T	After end of HBs open reading frame
Entecavir (ETV)	rtI169T	sF161H/L
	rtT184A	No change
	rtT184C	sL175F + sL176V
	rtT184I	No change
	rtT184G	sL176V
	rtT184S	sL175F
	rtT184M	sL176¹
	rt184L	sL175F
	rtS202C	No change/sS193F
	rtS202I	sV194F/S
	rtS202G	No change/sS193L
	rtM250I	After end of HBs open reading frame
	rtM250V	After end of HBs open reading frame

¹Stop codon;

²Cross-resistance. HBsAg: Hepatitis B surface antigen. Modified from Zoulim et al[38].

Citation: Caligiuri P, Cerruti R, Icardi G, Bruzzone B. Overview of hepatitis B virus mutations and their implications in the management of infection. World J Gastroenterol 2016; 22(1): 145-154
URL: https://www.wjgnet.com/1007-9327/full/v22/i1/145.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i1.145