Primary antibiotic resistance of Helicobacter pylori strains isolated from patients with dyspeptic symptoms in Beijing: A prospective serial study

Table 3 Influencing factors of antibiotic resistance of Helicobacter pylori isolates

Resistance rate (%)	GenderMale (n = 670),female (n = 651)	Age (yr)18-35 (n = 496),36-50 (n = 378),51-75 (n = 447)	Endoscopic findingsPUD (n = 244),NUD (n = 1077)
Amoxicillin	5.1, 5.1	4.2, 5.3, 5.8	2.9, 5.6
Clarithromycin	46.6, 51.6	50.8, 48.7, 47.4	36.5, 51.9a (OR = 1.822; 95%CI: 1.364-2.433)
Metronidazole	59.4, 69.4a (OR =1.504; 95%CI: 1.195-1.891)	63.3, 62.2, 67.3	58.6, 65.6
Levofloxacin	43.6, 54.8a (OR =1.518; 95%CI: 1.219-1.891)	42.9, 53.4, 52.3a (OR =1.199; 95%CI: 1.053-1.365)	45.1, 50.0
Tetracycline	7.2, 6.0	6.7, 4.5, 8.3	6.1, 6.7
Rifampicin	19.0, 15.8	16.7, 16.9, 18.6	20.9, 16.6

^aP < 0.05, the significant difference in levofloxacin resistence rate was observed among different age groups. PUD: Peptic ulcer disease; NUD: Non-ulcer disease; OR: Odds ratio; CI: Confidence interval.