Retrospective Cohort Study
Copyright ©The Author(s) 2015.
World J Gastroenterol. Mar 7, 2015; 21(9): 2668-2676
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2668
Table 5 Relationship between clinicopathologic characteristics, the systemic inflammatory or immunologic response, and overall survival in gastric cancer
VariableUnivariate analysis
Multivariate analysis
HR (95%CI)P valueHR (95%CI)P value
Age (yr)2.68 (1.46-4.92)0.00162.34 (1.25-4.37)0.0083
Tumor size (cm)4.47 (2.38-8.37)< 0.0001
T category (T1-2 vs T3-4)5.12 (2.63-9.98)< 0.0001
N category (N0 vs N1-3)3.57 (1.92-6.64)0.0001
TNM Stage (I-II vs III)6.28 (3.41-11.55)< 0.00015.53 (2.96-10.34)< 0.0001
Lymphatic invasion2.88 (1.56-5.28)0.0007
Vascular invasion2.71 (0.97-7.63)0.0583
Albumin (g/dL)0.27 (0.14-0.52)0.0001
AMC (/μL)2.41 (1.21-4.79)0.0125
ALC (/μL)0.31 (0.16-0.58)0.0003..
Hemoglobin (g/dL)0.40 (0.22-0.73)0.0030
Platelet (× 103/μL)2.11 (1.14-3.93)0.0188
MPV (fL)0.52 (0.28-0.97)0.0415
NLR2.21 (1.17-4.19)0.0155
PLR3.18 (1.70-5.97)0.0003
AMLPS1
High- vs intermediate-risk20.08 (0.03-0.21)< 0.00010.17 (0.06-0.45)0.0004
High- vs low-risk30.20 (0.09-0.44)< 0.00010.30 (0.13-0.71)0.0057
1AMLPS (AMC/ALC prognostic score) was defined as low-risk (both AMC ≤ 672.4/μL and ALC > 1734/μL), intermediate-risk (either AMC > 672.4/μL or ALC ≤ 1734/μL) and high-risk (both AMC > 672.4/μL and ALC ≤ 1734/μL);
2Statistically significant after adjusting for age, tumor size, T category, N category, TNM stage, lymphatic invasion, vascular invasion, serum albumin concentration, hemoglobin concentration, platelet count, MPV, NLR, PLR, and low-risk AMLPS;
3Statistically significant after adjusting for age, tumor size, T category, N category, TNM stage, lymphatic invasion, vascular invasion, serum albumin concentration, hemoglobin concentration, platelet count, MPV, NLR, PLR, and intermediate-risk AMLPS. Hazard ratio (HR) was obtained by Cox’s proportional hazard model. TNM: Tumor node metastasis; AMC: Absolute monocyte count; ALC: Absolute lymphocyte count; MPV: Mean platelet volume; NLR: Neutrophil/lymphocyte count ratio; PLR: Platelet/lymphocyte count ratio.