Retrospective Cohort Study
Copyright ©The Author(s) 2015.
World J Gastroenterol. Mar 7, 2015; 21(9): 2668-2676
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2668
Table 4 Relationship between clinicopathologic characteristics, the systemic inflammatory or immunologic response, and disease-free survival in gastric cancer
VariableUnivariate analysis
Multivariate analysis
HR (95%CI)P valueHR (95%CI)P value
Age (yr)3.32 (1.50-7.35)0.00323.33 (1.50-7.40)0.0032
Tumor size (cm)4.92 (2.79-8.69)< 0.0001
T category (T1-2 vs T3-4)7.26 (3.82-13.81)< 0.0001
N category (N0 vs N1-3)5.16 (2.87-9.27)< 0.0001
TNM Stage (I-II vs III)8.93 (5.08-15.69)< 0.00014.69 (2.15-10.24)0.0001
Lymphatic invasion3.63 (2.08-6.32)< 0.0001
Vascular invasion2.96 (1.17-7.47)0.0214
Albumin (g/dL)0.29 (0.16-0.51)< 0.0001
AMC (/μL)2.06 (1.08-3.92)0.0285
ALC (/μL)0.37 (0.21-0.64)0.0004
Hemoglobin (g/dL)0.32 (0.19-0.56)< 0.0001
Platelet (× 103/μL)2.45 (1.41-4.26)0.0015
MPV (fL)0.38 (0.18-0.77)0.0080
NLR2.18 (1.22-3.88)0.0085
PLR2.94 (1.68-5.13)0.0002
AMLPS1
High- vs intermediate-risk20.11 (0.05-0.26)< 0.00010.23 (0.10-0.56)0.0011
High- vs low-risk30.24 (0.11-0.52)0.00040.40 (0.18-0.90)0.0274
1AMLPS (AMC/ALC prognostic score) was defined as low-risk (both AMC ≤ 672.4/μL and ALC > 1734/μL), intermediate-risk (either AMC > 672.4/μL or ALC ≤ 1734/μL) and high-risk (both AMC > 672.4/μL and ALC ≤ 1734/μL);
2Statistically significant after adjusting for age, tumor size, T category, N category, TNM stage, lymphatic invasion, vascular invasion, serum albumin concentration, hemoglobin concentration, platelet count, MPV, NLR, PLR, and low-risk AMLPS;
3Statistically significant after adjusting for age, tumor size, T category, N category, TNM stage, lymphatic invasion, vascular invasion, serum albumin concentration, hemoglobin concentration, platelet count, MPV, NLR, PLR, and intermediate-risk AMLPS. Hazard ratio (HR) was obtained by Cox’s proportional hazard model. TNM: Tumor node metastasis; AMC: Absolute monocyte count; ALC: Absolute lymphocyte count; MPV: Mean platelet volume; NLR: Neutrophil/lymphocyte count ratio; PLR: Platelet/lymphocyte count ratio.